“…Brain microglia respond to neurodegenerative diseases with complex reactions via the induction of a pro-inflammatory phenotype, and may secrete NVs, EXs and/or EMVs enriched in potentially pathogenic miRNAs such as the Let-7 series of miRNA-like ssRNAs, miRNA-7, miRNA-9, miRNA-30b, miRNA-34a, miRNA-125b, miRNA-146a, miRNA-155, miRNA-450b and others that are known to promote neuro-inflammation and amyloidogenesis, induce complement activation, disrupt innate-immune signaling and deregulate the expression of neuron-specific phosphoproteins involved in neurotropic support and synaptic signaling [ 98 , 99 , 100 , 101 , 102 , 103 , 104 ];…”