Insights into the function of IgD

Edholm, Eva-Stina; Bengtén, Eva; Wilson, Melanie

doi:10.1016/j.dci.2011.03.002

Cited by 93 publications

(78 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Second, A. davidianus IgD possesses a much shorter constant region than other amphibian IgD. IgD in various vertebrates displays remarkable structural plasticity in terms of the number of C H domains (Danilova et al, 2005;Edholm et al, 2011;. It tends to have more C H domains in non-mammalian vertebrates (eight or more C H ) than in placental mammals (two or three C H ) Ramirez-Gomez et al, 2012;Zhao et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus

Zhu

Chen

Wang

et al. 2014

Developmental & Comparative Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus

Zhu

Chen

Wang

et al. 2014

Developmental & Comparative Immunology

View full text Add to dashboard Cite

“…There are 3 types of IgDC cells: IgMC/IgDC B cells, IgM-/ IgDC B cells, and an IgDC granulocyte population that express exogenously-derived IgD by means of a putative IgD-binding receptor and are negative for IgD, IgM, and TCR transcript. 113,114 Intriguingly, analysis of secreted IgD transcripts shows the absence of a V domain, and IgM-/IgDC B cells are thought to expand in response to certain pathogens and the Fc region serves as a pattern recognition molecule, similar to human IgD. Currently no work has been carried out examining the role of this B cell subset in the mucosal sites of the channel catfish.…”

Section: Adaptive Immunity At Catfish Mucosal Barriersmentioning

confidence: 99%

Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.)

et al. 2015

View full text Add to dashboard Cite

The mucosal barriers of catfish (Ictalurus spp) constitute the first line of defense against pathogen invasion while simultaneously carrying out a diverse array of other critical physiological processes, includ\ing nutrient adsorption, osmoregulation, waste excretion, and environmental sensing. Catfish depend more heavily on mucosal barriers than their terrestrial counterparts as they are continuously interacting with the aquatic microbiota. Our understanding of these barriers, while growing, is still limited relative to that of mammalian model systems. Nevertheless, a combination of molecular and cellular studies in catfish over the last few decades, and particularly within the last few years, has helped to elucidate many of the primary actors and pathways critical to their mucosal health. Here we describe aspects of innate and adaptive immune responses in the primary mucosal tissues (skin, gill, and intestine) of catfish, focusing on mucus-driven responses, pathogen recognition, soluble mediators, and immunoglobulin and T-cell derived immunity. Modulation of mucosal barriers will be critical moving forward for crafting better diets, improving vaccine delivery, enhancing water quality, and ensuring sustainable production practices in catfish.

show abstract

“…In placental mammals, IgD is primarily expressed in the form of membrane-bound B cell receptors, but it can also be expressed in a secreted form, albeit at very low levels (17). In this study, ostrich IgD was only detected in the membrane-bound form at the RNA level.…”

Section: Discussionmentioning

confidence: 64%

“…In addition to these unique functions, IgD also differs greatly from IgM from an evolutionary viewpoint (15,17). Since it was confirmed in 2006 that IgD is orthologous to IgW in lungfish and cartilaginous fish (12), this IgH isotype has now been identified in a large number of vertebrates.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds

Han

Yuan

Wang

et al. 2016

The Journal of Immunology

View full text Add to dashboard Cite

Although evolutionarily just as ancient as IgM, it has been thought for many years that IgD is not present in birds. Based on the recently sequenced genomes of 48 bird species as well as high-throughput transcriptome sequencing of immune-related tissues, we demonstrate in this work that the ostrich (Struthio camelus) possesses a functional δ gene that encodes a membrane-bound IgD H chain with seven CH domains. Furthermore, δ sequences were clearly identified in many other bird species, demonstrating that the δ gene is widely distributed among birds and is only absent in certain bird species. We also show that the ostrich possesses two μ genes (μ1, μ2) and two υ genes (υ1, υ2), in addition to the δ and α genes. Phylogenetic analyses suggest that subclass diversification of both the μ and υ genes occurred during the early stages of bird evolution, after their divergence from nonavian reptiles. Although the positions of the two υ genes are unknown, physical mapping showed that the remaining genes are organized in the order μ1-δ-α-μ2, with the α gene being inverted relative to the others. Together with previous studies, our data suggest that birds and nonavian reptile species most likely shared a common ancestral IgH gene locus containing a δ gene and an inverted α gene. The δ gene was then evolutionarily lost in selected birds, whereas the α gene lost in selected nonavian reptiles. The data obtained in this study provide significant insights into the understanding of IgH gene evolution in tetrapods.

show abstract

Insights into the function of IgD

Cited by 93 publications

References 79 publications

Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus

Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus

Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.)

Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds

Contact Info

Product

Resources

About