Acetaminophen (AP) is a widely used antipyretic analgesic belonging to the class of PPCPs, which is di cult to be effectively degraded by traditional water treatment processes. However, photocatalytic technology may be an effective approach. Herein, B-doped TiO 2 photocatalytic materials were synthesized by sol-gel method, calcinated at 600℃ for 2 h, investigated by XRD, TEM, XPS and other characterization methods. The photocatalytic e ciency and factors affecting the photocatalytic activity were assessed by degradation of AP under 365 nm UV light. Compared with naked TiO 2 , 4%B-TiO 2 nanopowder had smaller grain size, higher porosity and lower bandgap energy of 3.11 eV. Scavenging experiments and ESR results showed that •OH was the principal active species. Hence, the degradation e ciency of AP was as high as 98.8% in 30 min when adopting 10 mg/L AP initial concentration and 1 g/L 4%B-TiO 2 loading, owing to e cient •OH generated by B-TiO 2 .