Insights into the degradation and toxicity difference mechanism of neonicotinoid pesticides in honeybees by mass spectrometry imaging

Zhang, Yue; Chen, Dong; Du, Mingyi; Ma, Lianlian; Li, Ping; Qin, Run; Yang, Jiaru; Yin, Zhibin; Wu, Xinzhou; Han-hong, XU

doi:10.1016/j.scitotenv.2021.145170

Cited by 33 publications

(25 citation statements)

References 61 publications

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“…Due to their high efficacy for insect control and ease of application, neonicotinoids have quickly become the most widely used insecticides in agriculture, veterinary, and residential environments [4] . Based on the actual insecticide consumption, neonicotinoid have a share of approximately 30% of the global market for insecticides [5,6] . They have a similar chemical structure to nicotine, and as such are classified into N-nitroguanidines (i.e., imidacloprid, thiamethoxam, clothianidin, and dinotefuran) and N-cyanoamidines (i.e., acetamiprid and thiacloprid) [4,7] .…”

Section: Introductionmentioning

confidence: 99%

Determination and dietary risk assessment of neonicotinoid and insect growth regulators in honey

Abafe¹,

Chokwe²

2021

JEEA

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Aim: The aim of this study was to determine the presence, concentrations, dietary intake, and risk of residues of neonicotinoids (NEO) and insect growth regulators (IGR) in commercially available honey in South Africa. Methods: Sample preparation for honey was based on the “dilute and shoot” principle, followed by analysis using an internally validated ultra-high-performance liquid chromatographic coupled to tandem mass spectrometric method. Estimated daily intake and acute and chronic hazard quotients were determined to measure human exposure and health risk to NEO and IGR as well as the risk posed to honeybee. Results: NEO and IGR were detected in 50% and 21% of the 115 honey samples, respectively. The average concentration ranged 0.062-6.50 µgkg-1 and 0.479-1.644 µgkg-1 for NEO and IGR, respectively. While acetamiprid was the most detected (24.35%) NEO, imidacloprid presented the highest concentration (16.945 µg kg-1) in a sample. IGR co-occurred at variable concentrations with NEO in honey samples. The estimated daily intakes (EDI) of NEO and IGR ranged from 9.35 × 10-7 to 4.93 × 10-6 mg kg-1 bwd-1. The chronic hazard quotient (HQc) and acute hazard quotient (HQa) for NEO and IGR were considerably < 1, indicating negligible risk to human health and honeybee population. Conclusion: A UHPLC-MS/MS method was validated for the simultaneous determination of neonicotinoids and insect growth regulators in honey. Overall, the result of the present study confirms the widespread occurrence of NEO and IGR in honey consumed in South Africa. The EDIs, HQc, and HQa indicate that exposure to all target NEO and IGR via honey consumption constitutes negligible human health risk; however, the consequences of multiple routes of exposure to NEO and IGR cannot be overemphasized.

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Section: Introductionmentioning

confidence: 99%

Determination and dietary risk assessment of neonicotinoid and insect growth regulators in honey

Abafe¹,

Chokwe²

2021

JEEA

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“…Imidacloprid (MW 255.7, computed Log P = 1.84, H-bond donors = 1, H-bond acceptors = 7 and rotatable bond = 3) [56] is poorly ionised in neutral media, can easily penetrate the cuticle of Apis mellifera [61]. Other neonicotinoids as dinotefuran (MW 203.22, computed Log P = 0, H-bond donors = 3, H-bond acceptors = 4 and rotatable bond = 5) [62] and acetamiprid (MW 222.7, computed Log P = 0.56, H-bond donors = 0, H-bond acceptors = 4 and rotatable bond = 4) [56,63] can also quickly penetrate the integument of honey bees after contact [64]. Other insecticides such as malathion (MW 330.4, computed log P = 0.9, H-bond donors = 0, H-bond acceptors = 6 and rotatable bond = 11) [56,65] penetrate through the cuticle, distributed to haemolymph and other internal organs after topical application on Musca domestica [66].…”

Section: Discussionmentioning

confidence: 99%

Contact Toxicity of Various Stemona Collinsiae Root Extracts Against Periplaneta Americana (Dictyoptera: Blattodea) And Detection of Didehydrostemofoline Distribution in Tissue Using MALDI Imaging Mass Spectrometry

Sakulpanich¹,

Ounklong²,

Sommanat³

et al. 2021

Preprint

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Contact toxicity against Periplaneta americana has never been tested with S. collinsiae root extract. Hexane, dichloromethane, ethanol and water extracts were tested in final-instar nymphs and adult P. americana by topical application method. The dichloromethane extract showed the high-est potency of contact toxicity against the final-instar nymphs (41-100% corrected mortality at 48 hours), lowest LC50 (1.5±0.2 %w/v at 48 hours), and lowest LT50 (36.1±0.8 hours at 10%w/v) while the water crude extract lacked the contact toxicity (0-0% corrected mortality at 48 hours). Signs of toxicity, such as excited movement, trembling body, motionlessness, and swollen abdomen segment including irregularly extended foregut were found at the both stages of P. americana dropping with solutions of dichloromethane extract. Detection of didehydrostemofoline distri-bution using IMS revealed that didehydrostemofoline distributed in the tissue of the dead fi-nal-instar nymph and adult P. americana contacting with dichloromethane extract, but it was not found in tissue of euthanized P. americana which exposed to the water extract. Didehydrostemo-foline in the extract was a cause of toxicity signs and death of P. americana via a contact route. Thus, dichloromethane extract and didehydrostemofoline could be used as an active ingredient and chemical marker in aerosol and spray formulations for cockroach control.

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“…A built in-house reflection time-of-flight mass spectrometer was built as reported earlier, with a few modifications (see Figure S1 in the Supplementary Materials ) [ 12 , 35 ]. Briefly, a 355 nm laser with a 5 ns pulse duration and a 10 Hz repetition rate (Minilite II, Continuum Inc., West Newton, MA, USA) was adopted in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Benefiting from in situ detection and little sample preparation, this technique allows for the mapping of pesticides on the surface of tomato plants and their penetration and persistence in basil leaves [ 10 , 11 ]. Mass spectrometry imaging (MSI) has emerged as a unique technique for visualizing the spatiotemporal evolution of pesticides within biological tissues, with the advantages of label-free and nonspecific detection [ 12 , 13 ]. Among the available techniques, desorption electrospray ionization (DESI) can be used to monitor pesticide distribution both on the surface of leaves and in the cross section of plant stems [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

Qin

et al. 2021

Nanomaterials

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Food safety issues caused by pesticide residue have exerted far-reaching impacts on human daily life, yet the available detection methods normally focus on surface residue rather than pesticide penetration to the internal area of foods. Herein, we demonstrated gold nanoparticle (AuNP)-immersed paper imprinting mass spectrometry imaging (MSI) for monitoring pesticide migration behaviors in various fruits and vegetables (i.e., apple, cucumber, pepper, plum, carrot, and strawberry). By manually stamping food tissues onto AuNP-immersed paper, this method affords the spatiotemporal visualization of insecticides and fungicides within fruits and vegetables, avoiding tedious and time-consuming sample preparation. Using the established MSI platform, we can track the migration of insecticides and fungicides into the inner region of foods. The results revealed that both the octanol-water partition coefficient of pesticides and water content of garden stuffs could influence the discrepancy in the migration speed of pesticides into food kernels. Taken together, this nanopaper imprinting MSI is poised to be a powerful tool because of its simplicity, rapidity, and easy operation, offering the potential to facilitate further applications in food analysis. Moreover, new perspectives are given to provide guidelines for the rational design of novel pesticide candidates, reducing the risk of food safety issues caused by pesticide residue.

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Insights into the degradation and toxicity difference mechanism of neonicotinoid pesticides in honeybees by mass spectrometry imaging

Cited by 33 publications

References 61 publications

Determination and dietary risk assessment of neonicotinoid and insect growth regulators in honey

Determination and dietary risk assessment of neonicotinoid and insect growth regulators in honey

Contact Toxicity of Various Stemona Collinsiae Root Extracts Against Periplaneta Americana (Dictyoptera: Blattodea) And Detection of Didehydrostemofoline Distribution in Tissue Using MALDI Imaging Mass Spectrometry

Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

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