Insights into the antitumor mechanism of ginsenosides Rg3

Liu, Zongyu; Liu, Tongjun; Li, Wei; Li, Jiannan; Wang, Cuizhu; Zhang, Kai

doi:10.1007/s11033-021-06187-2

Cited by 24 publications

(18 citation statements)

References 112 publications

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“…Among 150 different types of ginsenoside extracted from Panax ginseng , Rg3 is the most frequently investigated ingredient in studies for cancers [ 27 ] ( Supplementary Table 1 ). One of noteworthy features of ginsenoside Rg3 is its structure—steroid glycoside—which reasonably explains its immune regulation capacity and steroid-like anti-inflammatory activity [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3, a promising agent for NSCLC patients in the pandemic: a large-scale data mining and systemic biological analysis

Zhuang

Chen²,

Zhong³

et al. 2023

Journal of Ginseng Research

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3, a promising agent for NSCLC patients in the pandemic: a large-scale data mining and systemic biological analysis

Zhuang

Chen²,

Zhong³

et al. 2023

Journal of Ginseng Research

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“…For instance, the ginsenoside Rg1 downregulated miR15-b to induce angiogenesis in an increased VEGFR-2 manner ( Chan et al, 2013 ). Notwithstanding the double-edged sword role of ginsenoside Rg3 in tumor angiogenesis is worth discussing, it was broadly considered an anti-angiogenic agent by modulating pro-angiogenic factors VEGF, FGF, and MMP ( Nakhjavani et al, 2020 ; Liu et al, 2021a ). Most recently, Rg3 was reported to induce angiogenesis inhibition in precancerous lesions of gastric cancer through lessening GLUT1 and GLUT4 ( Zeng et al, 2022 ).…”

Section: The Role Of Ethnopharmacology In Tumor Angiogenesismentioning

confidence: 99%

Co-Targeting Tumor Angiogenesis and Immunosuppressive Tumor Microenvironment: A Perspective in Ethnopharmacology

et al. 2022

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Tumor angiogenesis is one of the most important processes of cancer deterioration via nurturing an immunosuppressive tumor environment (TME). Targeting tumor angiogenesis has been widely accepted as a cancer intervention approach, which is also synergistically associated with immune therapy. However, drug resistance is the biggest challenge of anti-angiogenesis therapy, which affects the outcomes of anti-angiogeneic agents, and even combined with immunotherapy. Here, emerging targets and representative candidate molecules from ethnopharmacology (including traditional Chinese medicine, TCM) have been focused, and they have been proved to regulate tumor angiogenesis. Further investigations on derivatives and delivery systems of these molecules will provide a comprehensive landscape in preclinical studies. More importantly, the molecule library of ethnopharmacology meets the viability for targeting angiogenesis and TME simultaneously, which is attributed to the pleiotropy of pro-angiogenic factors (such as VEGF) toward cancer cells, endothelial cells, and immune cells. We primarily shed light on the potentiality of ethnopharmacology against tumor angiogenesis, particularly TCM. More research studies concerning the crosstalk between angiogenesis and TME remodeling from the perspective of botanical medicine are awaited.

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“…As a crucial ancient Chinese herbal material, Panax ginseng exerts prominent functions on a variety of diseases [ 12 ]. As an important Chinese medicinal material, ginseng has the functions of recovering meridians and astringing consciousness loss, replenishing the spleen and kidney, and calming the spirit with marked effects for relieving nerves and improving the immune system [ 13 ].…”

Section: The Precision Agriculture System For Ginsengmentioning

confidence: 99%

Algorithm for wireless sensor networks in ginseng field in precision agriculture

Chen

Xie

et al. 2022

PLoS ONE

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In the research on energy-efficient networking methods for precision agriculture, a hot topic is the energy issue of sensing nodes for individual wireless sensor networks. The sensing nodes of the wireless sensor network should be enabled to provide better services with limited energy to support wide-range and multi-scenario acquisition and transmission of three-dimensional crop information. Further, the life cycle of the sensing nodes should be maximized under limited energy. The transmission direction and node power consumption are considered, and the forward and high-energy nodes are selected as the preferred cluster heads or data-forwarding nodes. Taking the cropland cultivation of ginseng as the background, we put forward a particle swarm optimization-based networking algorithm for wireless sensor networks with excellent performance. This algorithm can be used for precision agriculture and achieve optimal equipment configuration in a network under limited energy, while ensuring reliable communication in the network. The node scale is configured as 50 to 300 nodes in the range of 500 × 500 m2, and simulated testing is conducted with the LEACH, BCDCP, and ECHERP routing protocols. Compared with the existing LEACH, BCDCP, and ECHERP routing protocols, the proposed networking method can achieve the network lifetime prolongation and mitigate the decreased degree and decreasing trend of the distance between the sensing nodes and center nodes of the sensor network, which results in a longer network life cycle and stronger environment suitability. It is an effective method that improves the sensing node lifetime for a wireless sensor network applied to cropland cultivation of ginseng.

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Insights into the antitumor mechanism of ginsenosides Rg3

Cited by 24 publications

References 112 publications

Ginsenoside Rg3, a promising agent for NSCLC patients in the pandemic: a large-scale data mining and systemic biological analysis

Ginsenoside Rg3, a promising agent for NSCLC patients in the pandemic: a large-scale data mining and systemic biological analysis

Co-Targeting Tumor Angiogenesis and Immunosuppressive Tumor Microenvironment: A Perspective in Ethnopharmacology

Algorithm for wireless sensor networks in ginseng field in precision agriculture

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