Insights into the antibacterial mechanism of MoS2/CoS2 heterostructure nanozymes with double enzyme-like activities for MRSA-infected wound therapy

Revealing the intrinsic peroxidase-like catalytic mechanism of O-doped CoS2 nanoparticles

“…Up to now, research studies on the catalytic mechanisms of nanozymes have developed from the description of the catalytic processes, [3][4][5][6][7] exposition of structure-activity relationships, 8,9 recognition of activity sites 10,11 to activity prediction, [12][13][14] aiming for the rational and accurate design of highly effective nanozymes. 15 To date, mechanisms for the enzyme-like activities of noble metals, 3,16 metal oxides, 12,17,18 transition-metal sulfides, 19 and carbon materials, 11,20 etc. have been explored.…”

“…24 Notably, its catalytic properties can be rationally modulated by various strategies such as defect engineering, 25,26 lattice shrinking, 27 and integration with other compounds. 19,28 These unique properties made it a promising nanozyme with broad applications in biomedical and environmental fields. As a POD mimetic catalyst, the CoS 2 nanozyme has exhibited high utilization value in bacterial sterilization 19,28 cancer treatment, 23 and degradation of persistent pollutants.…”

“…19,28 These unique properties made it a promising nanozyme with broad applications in biomedical and environmental fields. As a POD mimetic catalyst, the CoS 2 nanozyme has exhibited high utilization value in bacterial sterilization 19,28 cancer treatment, 23 and degradation of persistent pollutants. 29 But the present work mainly emphasized its application and gave a little illustration of the catalytic mechanism.…”

“…To date, mechanisms for the enzyme-like activities of noble metals, 3,16 metal oxides, 12,17,18 transition-metal sulfides, 19 and carbon materials, 11,20 etc . have been explored.…”

A polyoxometalate-based heterojunction nanozyme with peroxidase-mimic catalytic activity for sensitive biomolecule detection

“…21 Interestingly, constructing a heterojunction structure can also further enhance the enzymatic activity of these nanozymes via accelerating the electron transfer on the heterogeneous interface and reducing the required energy for the binding between nanozymes and H 2 O 2 . [22][23][24] Based on the aforementioned ndings, we assume that polyoxometalate-based heterojunctions can act as prospective POD-like nanozymes for biosensing.…”