Insights Into Stem Cell Aging

Herrera-Merchan, Antonio; Hidalgo, Isabel; Arranz, Lorena; González, Susana

doi:10.5772/32121

Cited by 1 publication

(1 citation statement)

References 61 publications

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“…The asymmetrical division of LT-HSCs gives rise to short-term repopulating HSCs (ST-HSCs), the asymmetrical division of which is the source of the multipotent progenitor cells (MPP-HSCs). The difference among these cells' characteristics is gradual loss of self-renewal potential, but they sustain the same ability to transform into all blood cell types [51]. Further asymmetrical divisions of MPP-HSCs give slowly proliferating BFU-E and then rapidly dividing CFU-E progenitor cells, which divide three to five times within two to three days.…”

Section: Erythropoiesismentioning

confidence: 99%

Role of Extrinsic Apoptotic Signaling Pathway during Definitive Erythropoiesis in Normal Patients and in Patients with β-Thalassemia

Raducka-Jaszul

Bogusławska

Jędruchniewicz

et al. 2020

IJMS

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Apoptosis is a process of programmed cell death which has an important role in tissue homeostasis and in the control of organism development. Here, we focus on information concerning the role of the extrinsic apoptotic pathway in the control of human erythropoiesis. We discuss the role of tumor necrosis factor α (TNFα), tumor necrosis factor ligand superfamily member 6 (FasL), tumor necrosis factor-related apoptosis-inducing (TRAIL) and caspases in normal erythroid maturation. We also attempt to initiate a discussion on the observations that mature erythrocytes contain most components of the receptor-dependent apoptotic pathway. Finally, we point to the role of the extrinsic apoptotic pathway in ineffective erythropoiesis of different types of β-thalassemia.

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Section: Erythropoiesismentioning

confidence: 99%