Insights into Novel Antimicrobial Based on Chitosan Nanoparticles: From a Computational and Experimental Perspective

Assis, Letícia C.; Lima, Nerilson Marques; Andrade, Teresinha J A S; Cordeiro, Patrícia Hissae Yassue; Taft, Carlton A.; Porta, Felipe de Almeida La

doi:10.1007/978-3-030-31403-3_4

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“…6 Chitosan is a natural polymer with both biocompatibility and antibacterial property, which inhibits the synthesis of mRNA and protein via penetration into the nuclei of bacteria and binding with DNA. 7,8 Although chitosan-based films exhibit good bactericidal activity, their poor mechanical properties, such as, tensile strength and flexibility, restrict their biomedical applications, especially as wound dressings. 9 To improve the flexibility and tensile strength, some researchers have employed the incorporation of chitosan and liquid silicone rubber (SR) as an alternative.…”

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confidence: 99%

Preparation, characterization, and antibacterial activity of chitosan/silicone rubber filled zeolite, silver, and copper nanocomposites againstPseudomonas aeruginosaand methicillin‐resistantStaphylococcus aureus

Rezazadeh

Kianvash

2021

J of Applied Polymer Sci

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The ongoing emergence of antibiotic‐resistant bacteria has become one of the biggest threats to global health and development today. Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus (MRSA) are important antibiotic‐resistant bacteria due to their increasing resistance to a broad array of antimicrobial agents. Herein, we developed a novel antibacterial nanocomposite based on chitosan and liquid silicone rubber filled zeolite‐A, Ag, and Cu nanoparticles with remarkable antibacterial activity against P. aeruginosa and MRSA. The antibacterial activity of the nanocomposite was studied by disc diffusion and broth culture methods. Besides, the mechanical properties, wetting behavior, and chemical structure of the present nanocomposite were also investigated. The results exhibited that the inhibition zone diameter of the nanocomposite for P. aeruginosa and MRSA were 40 and 27 mm, respectively. It also took approximately 1 h to inhibit the growth of the tested bacteria. The nanocomposite sample with a thickness of around 1 mm showed an elastic elongation of nearly 49% and a contact angle of roughly 120°. Thus, the present nanocomposite was found to be useful in killing and inhibiting the growth of P. aeruginosa and MRSA, and it could also be qualified as a superior elastic and hydrophobic material.

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