Insights into Insulin and Glucagon Responses in Fish

Navarro, Isabel; Rojas, Pablo A.; Capilla, Encarnación; Albalat, Amaya; Castillo, Juan; Montserrat, Núria; Codina, Marta; Gutiérrez, Joaquím

doi:10.1023/b:fish.0000032726.78074.04

Cited by 69 publications

(44 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it is worth noting that arginine not only stimulates insulin secretion but also promotes glucagon release by endocrine pancreatic cells in fish (Mommsen and Plisetskaya, 1991;Navarro et al, 2002), which could explain the hyperglycemia observed 24·h after arginine administration in this and other studies . Therefore, the different effects of arginine treatment on btGLUT4 protein and mRNA levels in red muscle could be due to the fact that other factors, in addition to insulin, might be involved in the regulation of btGLUT4 protein levels by affecting the rate of btGLUT4 protein degradation or the translational efficiency of btGLUT4 transcripts.…”

Section: Discussionmentioning

confidence: 62%

Physiological regulation of glucose transporter (GLUT4) protein content in brown trout (Salmo trutta) skeletal muscle

Dı́az

Capilla

Planas

2007

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARY In brown trout, red and white skeletal muscle express the insulin-regulatable glucose transporter 4 (btGLUT4). We have previously shown that the mRNA expression of btGLUT4 in red muscle, but not white muscle, is altered under experimental conditions designed to cause changes in the plasma levels of insulin, such as fasting, insulin and arginine administration. In order to determine whether changes of btGLUT4 expression at the mRNA level are correlated with changes at the protein level, we performed in vivoexperiments to alter blood insulin concentrations and determined the abundance of btGLUT4 protein in trout red and white skeletal muscle by immunoblotting using an antibody to salmon GLUT4. In the present study we show that btGLUT4 protein content in red muscle decreases after fasting and increases after insulin administration. By contrast, btGLUT4 protein content in white muscle decreases after fasting but is not affected by insulin treatment. Our results show a good correlation between the changes observed in btGLUT4 protein and the previously reported changes in mRNA levels in response to alterations in circulating insulin, indicating that the regulation of btGLUT4 in brown trout takes place predominantly in the red skeletal muscle.

show abstract

Section: Discussionmentioning

confidence: 62%

Physiological regulation of glucose transporter (GLUT4) protein content in brown trout (Salmo trutta) skeletal muscle

Dı́az

Capilla

Planas

2007

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…As in mammals, insulin has an anabolic action in fish, enhancing lipid storage by activating lipogenesis, and increasing protein synthesis and body growth (Nelson and Sheridan, 2006). Insulin receptors are present in several tissues, including adipose tissue (Navarro et al 2002). In rainbow trout, insulin acts at several levels to promote lipid storage.…”

Section: Insulinmentioning

confidence: 99%

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture

Leaver

Bautista

Björnsson

et al. 2008

Reviews in Fisheries Science

222

189

View full text Add to dashboard Cite

Lipids are the predominant source of energy for fish. The mechanisms by which fish allocate energy from lipids, for metabolism, development, growth and reproduction are critical for understanding key life history strategies and transitions. Currently, the major lipid component in aquaculture diets is fish oil (FO), derived from wild capture fisheries that are exploited at their maximum sustainable limit. The increasing demand from aquaculture for FO will soon exceed supply and threaten the viability of aquaculture. Thus, it is essential to minimize FO use in aquaculture diets. This might be achieved by a greater understanding of lipid storage and muscle growth, or the identification of alternatives to FO in feeds. This review focuses on recent research applying molecular and genomic techniques to the study of fin-fish lipid metabolism from an aquaculture perspective. Accordingly, particular emphasis will be given to fatty acid metabolism and to highly unsaturated fatty acid (HUFA) biosynthesis, and to the transcriptional mechanisms and endocrine factors that regulate these processes in fish. Comparative studies of gene function and distribution are described which, when integrated with recent fish genome sequence information, provide insights into lipid homeostasis and the outcomes associated with the replacement of FO in fish diets.

show abstract

“…Several amino acids, including Lys, affect hormone secretion [16][17][18] and intracellular signaling pathways in fish [19]. Thus, dietary Lys levels probably affect energy metabolism including lipid accumulation in fish.…”

Section: Introductionmentioning

confidence: 99%

Pre-harvest Modulation of N-3 Long-chain Polyunsaturated Fatty Acids in Rainbow Trout Meat for Human Consumption

Yoshinaga¹,

Ushio²,

Haga³

et al. 2018

J Food Process Technol

View full text Add to dashboard Cite

Since post-harvest improvement of food quality depends on the pre-harvest stage, controlling food quality at the pre-harvest stage is being recognized as an important aspect of food processing technology. n-3 Long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are considered important factors in the suppression of cardiovascular disease and development of the infant brain and visual functions. Fish meat generally contains a larger amount of n-3 LCPUFAs than meat from terrestrial animals, but the amount of n-3 LCPUFAs in fish meat depends on their dietary fatty acid intake. In order to supply n-3 LCPUFAs to consumers, we developed a finishing-up method, through a 4-day lysine-deficient diet feeding for rainbow trout (Oncorhynchus mykiss) meat. This 4-day lysine deficiency did not affect fish body weight, while significantly increased the total lipid content in the muscle tissue. In addition, docosahexaenoic acid and total n-3 fatty acid contents increased significantly in the meat throughout the 4-day finishing treatment. We concluded that the finishing-up method using short-term lysine-deficient diet feeding enables us to enrich fish meat with n-3 fatty acids for human consumption.

show abstract

Insights into Insulin and Glucagon Responses in Fish

Cited by 69 publications

References 75 publications

Physiological regulation of glucose transporter (GLUT4) protein content in brown trout (Salmo trutta) skeletal muscle

Physiological regulation of glucose transporter (GLUT4) protein content in brown trout (Salmo trutta) skeletal muscle

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture

Pre-harvest Modulation of N-3 Long-chain Polyunsaturated Fatty Acids in Rainbow Trout Meat for Human Consumption

Contact Info

Product

Resources

About