Insights into Germline Development and Differentiation in Molluscs and Reptiles: The Use of Molecular Markers in the Study of Non-model Animals

Milani, Liliana; Maurizii, Maria Gabriella

doi:10.1007/978-3-030-23459-1_14

Cited by 1 publication

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“…The presence in many distantly related taxa of mitochondria associated with the germ plasm-material found in germ cells and containing germline determinants-suggested a general mechanism: mitochondria release material for germline specification/formation. Many studies on several animals documented the emission of mitochondrial material merging with germ plasm; this was observed in model organisms such as D. melanogaster, Hemicentrotus pulcherrimus, Xenopus laevis and M. musculus (see [33,34], and references therein), as well as in non-model organisms (e.g. : [35]).…”

Section: (B) An Example Of the Use Of Classes: The Link Between Mitochondria And Germline Formationmentioning

confidence: 99%

Faraway, so close. The comparative method and the potential of non-model animals in mitochondrial research

Milani

Ghiselli

2019

Phil. Trans. R. Soc. B

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One contribution of 15 to a theme issue 'Linking the mitochondrial genotype to phenotype: a complex endeavour'.Finding causal links between genotype and phenotype is a major issue in biology, even more in mitochondrial biology. First of all, mitochondria form complex networks, undergoing fission and fusion and we do not know how such dynamics influence the distribution of mtDNA variants across the mitochondrial network and how they affect the phenotype. Second, the non-Mendelian inheritance of mitochondrial genes can have sex-specific effects and the mechanism of mitochondrial inheritance is still poorly understood, so it is not clear how selection and/or drift act on mtDNA genetic variation in each generation. Third, we still do not know how mtDNA expression is regulated; there is growing evidence for a convoluted mechanism that includes RNA editing, mRNA stability/turnover, post-transcriptional and post-translational modifications. Fourth, mitochondrial activity differs across species as a result of several interacting processes such as drift, adaptation, genotype-by-environment interactions, mitonuclear coevolution and epistasis. This issue will cover several aspects of mitochondrial biology along the path from genotype to phenotype, and it is subdivided into four sections focusing on mitochondrial genetic variation, on the relationship among mitochondria, germ line and sex, on the role of mitochondria in adaptation and phenotypic plasticity, and on some future perspectives in mitochondrial research.This article is part of the theme issue 'Linking the mitochondrial genotype to phenotype: a complex endeavour'.

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Section: (B) An Example Of the Use Of Classes: The Link Between Mitochondria And Germline Formationmentioning

confidence: 99%

Faraway, so close. The comparative method and the potential of non-model animals in mitochondrial research

Milani

Ghiselli

2019

Phil. Trans. R. Soc. B

Self Cite

View full text Add to dashboard Cite

show abstract

Insights into Germline Development and Differentiation in Molluscs and Reptiles: The Use of Molecular Markers in the Study of Non-model Animals

Cited by 1 publication

References 143 publications

Faraway, so close. The comparative method and the potential of non-model animals in mitochondrial research

Faraway, so close. The comparative method and the potential of non-model animals in mitochondrial research

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