Insights into drug loading techniques with mesoporous silica nanoparticles: Optimization of operating conditions and assessment of drug stability

Khalbas, Ali H.; Albayati, Talib M.; Saady, Noori M. Cata; Zendehboudi, Sohrab; Salih, Issam K.; Tofah, Mohanad L.

doi:10.1016/j.jddst.2024.105698

Cited by 1 publication

(1 citation statement)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[12,13] Mesoporous silica nanoparticles (MSNs) are well-suited for biomedical applications and drug delivery due to their pore size range (2-50 nm). [14][15][16] The M41S family, which includes ordered, mesoporous silica, such as MCM-50 lamellar, MCM-48 cubic, and MCM-41, was first created in the early 1990 s. [17][18][19] MSNs hold great promise to enhance the coagulation cascade and trigger the hemostasis process with fewer side effects because they demonstrate the ability to control and tune particle size, surface charge, particle morphology, and surface area, which can affect the clotting process and activate factor XII and related proteins. [20,21] While a number of literature reviews have investigated the role of mesoporous silica in hemorrhage control, [4,13] there is a notable absence of in-depth comprehensive studies that investigate the general characteristics of mesoporous silica in relation to hemorrhage control.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

Albayati,

Alardhi,

Khalbas

et al. 2024

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence the toxicity of cells, the loading of therapeutic agents, and the release of active ions during the hemostasis process. Therefore, understanding the fundamentals of tuning these characteristics is important to design these types of carriers. While several literature reviews have explored the role of MSNs in hemorrhage control, comprehensive studies focusing on their general characteristics and specific applications remain scarce. This review concentrates on the principles of synthesizing mesoporous silica, the general types of MSNs, techniques for loading drugs methods onto the site of injury, release kinetics models, biocompatibility, toxicity, and the unique properties of MSNs. Furthermore, the article examines the mechanism of action of MSNs as nanomaterial hemostatic agents.

show abstract