Insights into biomonitoring of human exposure to polycyclic aromatic hydrocarbons with hair analysis: A case study in e-waste recycling area

Lin, Meiqing; Tang, Jian; Ma, Shengtao; Yu, Yingxin; Li, Guiying; Fan, Ruifang; Mai, Bi-Xian; An, Taicheng

doi:10.1016/j.envint.2019.105432

Cited by 41 publications

(25 citation statements)

References 45 publications

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“…Following exposure, PAHs are metabolically transformed into mono-, di-, and tetrahydroxylated metabolites (OH-PAHs) in human bodies ( Carmella et al 2004 ; Klotz et al 2011 ). Among these metabolites, mono OH-PAHs are used as biomarkers of PAHs exposure through the analysis of specimens such as urine, plasma, breast milk, and hair ( Guo et al 2013 ; Lin et al 2020 ; Oliveira et al 2020 ; Sun et al 2020 ; Zhu et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Zhu

Martinez-Moral

Kannan

2021

Environment International

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants. Urinary concentrations of mono-hydroxylated metabolites of PAHs (OH-PAHs) have been used as biomarkers of these chemicals’ exposure in humans. Little is known, however, with regard to intra- and inter-individual variability in OH-PAH concentrations and their association with oxidative stress. We conducted a longitudinal study of measurement of urinary concentrations of 15 OH-PAHs and 7 oxidative stress biomarkers (OSBs) of DNA damage [8-hydroxy-2′-deoxyguanosine (8-OHdG)], lipid [malondialdehyde (MDA) and F 2 -isoprostanes (PGF 2α )] and protein [ o,o ′ -dityrosine (diY)] peroxidation in 19 individuals for 44 consecutive days. Metabolites of naphthalene (OHNap), fluorene (OHFlu), phenanthrene (OHPhe), and pyrene (OHPyr) were found in >70% of 515 urine samples analyzed, at sum concentrations (∑OH-PAH) measured in the range of 0.46–60 ng/mL. After adjusting for creatinine, OHNap and ∑OH-PAH concentrations exhibited moderate predictability, with intra-class correlation coefficients (ICCs) ranging from 0.359 to 0.760. However, ICC values were low (0.001–0.494) for OHFlu, OHPhe, and OHPyr, which suggested poor predictability for these PAH metabolites. Linear mixed-effects analysis revealed that an unit increase in ∑OH-PAH concentration corresponded to 4.5%, 5.3%, 20%, and 21% increase in respective urinary 8-OHdG, MDA, PGF 2α , and diY concentrations, suggesting an association with oxidative damage to DNA, lipids, and proteins. The daily intakes of PAHs, calculated from urinary concentrations of OH-PAHs, were 10- to 100-fold below the current reference doses. This study provides valuable information to design sampling strategies in biomonitoring studies and in assigning exposure classifications of PAHs in epidemiologic studies.

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Section: Introductionmentioning

confidence: 99%

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Zhu

Martinez-Moral

Kannan

2021

Environment International

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“…The subjects included 29 EW (e-waste) dismantlers with the routine job of directly dismantling e-waste; 23 EW administrators who do other work like security, cleaning, and administration at the e-waste dismantling industrial park; 37 surrounding residents (19 juvenile residents, ≤14 years old; and 18 adult residents, >14 years old). Details about the sampling campaign are included in a previous publication Tables S1 and S2 summarize the characteristics of the study population.…”

Section: Methodsmentioning

confidence: 99%

Identifying Dermal Uptake as a Significant Pathway for Human Exposure to Typical Semivolatile Organic Compounds in an E-Waste Dismantling Site: The Relationship of Contaminant Levels in Handwipes and Urine Metabolites

Tang

Lin

et al. 2021

Environ. Sci. Technol.

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Dermal exposure to semivolatile organic compounds (SVOCs) has recently attracted widespread attention; understanding these exposures is particularly important for people whose skin is frequently exposed to different pollution surfaces. In this study, handwipes were collected from exposed occupational workers and local residents near a typical electronic waste (e-waste) dismantling area; urine samples were also sampled. The wipes were analyzed for three typical SVOCs: polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and organophosphate flame retardants (OPFRs). The median levels of PAHs, OPFRs, and PBDEs in handwipes from e-waste dismantlers were 96.0, 183, and 238 ng, respectively. The analytes were higher in the handwipes collected from workers than those from residents, indicating that they were subjected to greater dermal exposure during primitive e-waste dismantling activities. Among the three SVOCs, the strongest correlation was found between triphenyl phosphate (TPhP) in handwipes and diphenyl phosphate (DPhP) in paired urine; the next strongest correlations were between PAHs and PBDEs and their corresponding urinary metabolites. The results showed that TPhP contributed the highest exposure to e-waste dismantlers via dermal exposure. Our research highlights the importance of dermal exposure to TPhP, which should be considered in future exposure risk assessments.

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“…In Uganda, the E-waste generated in 2019 and placed in the market was 32 kilo tones (kt) whereas the E-waste that was documented and destined for collection and recycling in 2018 was at 0.18 kt (Forti et al, 2020). Several studies (Zhang et al, 2020;Lin et al, 2020;Awasthi et al, 2019;Maphosa and Maphosa, 2020) have considered the consequences of E-waste but fell short of providing solutions to address E-waste management in a developing country context despite the paucity of solid research. This study fills that gap with evidence from recent studies to mitigate the consequences of E-waste and also provide the potential of sustainable E-waste management based on the role of key actors.…”

Section: Problem Statementmentioning

confidence: 99%

Towards a sustainable electronic waste management in Uganda: A stakeholder perspective

Nyeko¹,

Mlay²,

Judith³

et al. 2022

Afr. J. Environ. Sci. Technol.

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The management of electrical and electronic waste (E-waste) requires a collaborative approach against unsustainable electronic waste management. This paper attempts to assess the role of E-waste actors in regard to E-waste management sustainability by evaluating their course of action. It proposes an Ewaste management conceptual framework based on key stakeholders and validates it with 346 top government employees in strategic positions across 10 Ugandan cities. The study utilized Partial Least Square (PLS) technique, a statistical analysis method well-known under Structural Equation Modeling (SEM), for data analysis. The calculated and considered model explains 48.5% of the variance in E-waste management sustainability. The results demonstrate that E-waste handlers role (β = 0.102, t = 2.004, p<0.05), financial institutions role (β = 0.268, t = 2.024, p < 0.05), local government role (β = 0.249, t = 3.612, p < 0.05), role of media (β = 0.316, t = 6.637, p < 0.05), and producer role (β = 0.144, t = 2.845, p<0.05) have significant influence on E-waste management sustainability. However, consumer role in Ewaste (β = -0.051, t = 0.838, p > 0.01) had an insignificant influence on E-waste management sustainability, although, its importance is discussed. The attention of policymakers and waste management planners is drawn towards strengthening the Public-Private Partnerships (PPP), fasttracking the implementation of the Extended Producer Responsibility (EPR) model as an E-waste management model and initiation of E-waste Web-based applications are some of the policy recommendations in this paper. This will ensure sound E-waste management practices for better public health and environmental outcomes.

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Insights into biomonitoring of human exposure to polycyclic aromatic hydrocarbons with hair analysis: A case study in e-waste recycling area

Cited by 41 publications

References 45 publications

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Identifying Dermal Uptake as a Significant Pathway for Human Exposure to Typical Semivolatile Organic Compounds in an E-Waste Dismantling Site: The Relationship of Contaminant Levels in Handwipes and Urine Metabolites

Towards a sustainable electronic waste management in Uganda: A stakeholder perspective

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