Insights in cyanobacteria lipidomics: A sterols characterization from Phormidium autumnale biomass in heterotrophic cultivation

Fagundes, Mariane Bittencourt; Falk, Renata Bolzan; Facchi, Michelle Maria Xavier; Vendruscolo, Raquel Guidetti; Maroneze, Mariana Manzoni; Zepka, Leila Queiroz; Jacob‐Lopes, Eduardo; Wagner, Róger

doi:10.1016/j.foodres.2018.10.060

Cited by 31 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the ninety's the researchers Sallal, Nimer, and Radwan [6] studied other cyanobacteria strains, and verified that after dark incubation, sterols concentration increased. In in agreement to this study, Fagundes et al [7] showed higher concentrations of sterols (β-sitosterol, stigmasterol, and cholesterol), for Phormidium autumnale cultured in heterotrophic system, being the inoculum without the presence of these compounds. In general, cyanobacteria are manly photosynthetic, but some strains can growth in heterotrophic conditions, in this context, it can be concluded that more studies on this particular area are necessary for further acquire more comprehension for biotechnological application.…”

Section: Algae Metabolism: Sterols Discoverysupporting

confidence: 92%

Sterols Biosynthesis in Algae

Fagundes¹,

Wagner²

2021

Biosynthesis [Working Title]

Self Cite

View full text Add to dashboard Cite

Sterols are secondary metabolites, they are considered bioactive, due to their recognized activity as antioxidants, anticarcinogenic, cardiovascular protectors, and antiviral capacity. These triterpenoids can be found in a wide range of concentrations in different algae strains, being the variations related to external factors. In the world, there are millions of algae, some strains have the ability to produce high-value phytosterols, like stigmasterol, and sitosterol, however, others could lead to cholesterol production. For this reason, understand the principal factors involved in sterols biosynthesis, allows us to appoint the algae strain for industrial application and escalating these specific compounds production. Some algae are capable to produce sterols from mevalonic acid pathway, other strains present the methylerythritol 4-phosphate (MEP), or 1-deoxy-D-xylulose-5-phosphate (DOXP) as the main pathway, each one is responsible for the production of plans of intermediary compounds. In this sense, this chapter summarizes current knowledge of the biosynthetic pathways responsible for different sterols formation, as well as, describe main sterols that could be isolated from algae metabolism.

show abstract

Section: Algae Metabolism: Sterols Discoverysupporting

confidence: 92%

Sterols Biosynthesis in Algae

Fagundes¹,

Wagner²

2021

Biosynthesis [Working Title]

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nakiterpiosin, and nakiterpiosinon are C-nor-D-homosteroids. Previous studies showed that cyanobacteria can produce sterols by the cyclization of squalene, a triterpene (65). In the Ca .…”

Section: Discussionmentioning

confidence: 99%

Prevalence, complete genome and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge,Terpios hoshinota

Chen

Yang

et al. 2021

Preprint

View full text Add to dashboard Cite

Terpios hoshinota is a ferocious, space-competing sponge that kills a variety of stony corals by overgrowth. Outbreaks of this species have led to intense coral reef damage and declines in living corals on the square kilometer scale in many geographical locations. Our large-scale 16S rRNA metagenome study across three oceans revealed that the core microbiome of T. hoshinota included OTUs related to Prochloron, Endozoicomonas, Pseudospirillum, SAR116, Magnetospira, and Ruegeria. A Prochloron-like OTU was the most dominant cyanobacterium in T. hoshinota in the western Pacific Ocean, South China Sea, and Indian Ocean. The high-quality draft genome of the Prochloron-like cyanobacterium and our pigment analysis revealed that, unlike the previously described Prochloron species and their genomes, this bacterium had phycobiliproteins and phycobilins and lacked chlorophyll b. Furthermore, the phylogenetic analyses demonstrated that the bacterium was phylogenetically distinct to Prochloron, strongly suggesting that it should be a sister taxon to Prochloron; we therefore proposed this symbiotic cyanobacterium as a novel species under a new genus: Candidatus Prochlorobium terpiosii. In addition, we also characterize the metabolic potentials of the cyanobacterium in carbon and nitrogen cycling and propose a model for the interaction between Ca. Pb. terpiosii LD05 and T. hoshinota. This study builds the foundation for T. hoshinota's microbiome and paves a way for understanding the ecosystem, invasion mechanism, and causes of outbreak of this coral-killing sponge.

show abstract

“…Fagundes et al [ 46 ], evaluated the production of sterols with antioxidant activity present in the cyanobacterium Phormidium autumnale , that were first isolated from the Cuatro Cienegas desert (Mexico) and, found stigmasterol (455.3 µg g −1 ) and also β-sitosterol (279.0 µg g −1 ), which are known by their high antioxidant activity and are produced by using different external carbon sources.…”

Section: Microalgae and Cyanobacteria As Metabolite Producersmentioning

confidence: 99%

“…Fagundes et al [ 46 ] studied the secondary metabolites produced by the cyanobacterium Phormidium autumnale using different carbon sources, including wastewater, in an attempt to observe and quantify the production of substances with biological activity produced by cyanobacteria. In this search for metabolites, several steroids were identified, some of which had the ability to lower the cholesterol level in human blood and, thus are being marketed as drugs.…”

Section: Cyanobacteria and Microalgae At Brazilmentioning

confidence: 99%

Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria

Oliveira

Costa

et al. 2020

Molecules

View full text Add to dashboard Cite

Due the worldwide need to improve care for the environment and people, there is a great demand for the development of new renewable, sustainable, and less polluting technologies for food, health, and environmental industries. The marine environment is one of the main areas investigated in the search for alternatives to the raw materials currently used. Thereby, cyanobacteria and marine microalgae are microorganisms that are capable of producing a diverse range of metabolites useful for their cellular maintenance, but that also represent a great biotechnological potential. Due its great potential, they have an enormous appeal in the scientific research where, the biological activity of metabolites produced by these microorganisms, such as the antioxidant action of sterols are, some examples of biotechnological applications investigated around the world. Thereby, Brazil due to its extensive biodiversity, has high potential as a raw material supplier of marine waters, researching cyanobacteria and microalgae metabolites and their applications. Thus, this rapid review intends to present some important contributions and advances from Brazilian researchers, using the biomass of Brazilian cyanobacteria and marine microalgae, in order to illustrate the value of what has already been discovered and the enormous potential of what remains unexplored so far.

show abstract

Insights in cyanobacteria lipidomics: A sterols characterization from Phormidium autumnale biomass in heterotrophic cultivation

Cited by 31 publications

References 39 publications

Sterols Biosynthesis in Algae

Sterols Biosynthesis in Algae

Prevalence, complete genome and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge,Terpios hoshinota

Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria

Contact Info

Product

Resources

About