Insights from the ganglionic acetylcholine receptor autoantibodies in patients with Sjögren’s syndrome

Mukaino, Akihiro; Nakane, Shunya; Higuchi, Osamu; Nakamura, Hideki; Miyagi, Tomo; Shiroma, Kanako; Tokashiki, Takashi; Fuseya, Yasuhiro; Ochi, Kazuhide; Umeda, Masataka; Nakazato, Tetsuya; Akioka, Shinji; Maruoka, Hiroyuki; Hayashi, Masatoshi; Igarashi, Shu ichi; Yokoi, Kohei; Maeda, Yukihide; Sakai, Waka; Matsuo, Hidenori; Kawakami, Atsushi

doi:10.3109/14397595.2016.1147404

Cited by 31 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because ataxic neuropathy was also present in two out of the three patients, the authors suspected T cell-mediated autonomic ganglionitis as a cause of autonomic dysfunction. Recently, Mukaino et al reported higher prevalence (80%) of anti-gAChR antibody in patients with SS with autonomic symptoms, compared with patients with SS with no autonomic symptoms (23.1%) 13. Although multiple mechanism (antimuscarinic acetylcholine receptor M3 antibodies, autoimmune ganglionitis and cytokines) has been proposed for the development of autonomic dysfunction in patients with SS, this report may also suggest the possible involvement of anti-gAChR antibody.…”

Section: Discussionmentioning

confidence: 58%

Autoimmune autonomic ganglionopathy associated with Sjögren’s syndrome presenting with recurrent abdominal distension

Yoshida

Kinjo²,

Nakane

2018

BMJ Case Reports

Self Cite

View full text Add to dashboard Cite

A 65-year-old woman with Sjögren’s syndrome presented with recurrent abdominal distension, constipation, weight loss, orthostatic dizziness, loss of sweating and incomplete emptying of the bladder. Gastrointestinal dilatation but no evidence of malignancy or obstruction was found on CT of the abdomen, oesophagogastroduodenoscopy or colonoscopy. Postvoiding residual urine volume was increased. Antiganglionic acetylcholine receptor antibody was positive. We diagnosed as autoimmune autonomic ganglionopathy. The patient responded to corticosteroid treatment. One year after treatment, she continued to have mild gastrointestinal symptoms, but overall condition was stable without further intervention.

show abstract

Section: Discussionmentioning

confidence: 58%

Autoimmune autonomic ganglionopathy associated with Sjögren’s syndrome presenting with recurrent abdominal distension

Yoshida

Kinjo²,

Nakane

2018

BMJ Case Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…We found that 9/39 (23.1%) patients with SS were seropositive and five of nine patients had autonomic symptoms. Moreover, we detected anti-gAChRα3 and anti-gAChRβ4 antibodies in 8/10 (80.0%) patients with SS with autonomic symptoms [15]. To identify the clinical characteristics of primary SS in patients with the gAChR antibodies, we obtained 22 serum samples (from 22 patients with primary SS) from teaching and general hospitals throughout Japan between January 2012 and March 2017 [145].…”

Section: Case Series and Prevalence Of Anti-gachr Antibodies In Sjögrmentioning

confidence: 99%

“…We performed the LIPS analysis with the α3 or β4 subunit fused to Gaussia Luciferase 8990 to measure the respective antibodies in human sera [9,14]. Recently, we determined the prevalence of anti-gAChR antibodies in autoimmune rheumatic diseases (ARD) including SS, SSc, RA, and SLE with this method [15][16][17]. In the present review, we aimed to critically examine the current literature on autonomic neuropathy and autonomic function tests and to propose that anti-gAChR antibodies provide a new perspective on the mechanism underlying autonomic dysfunction in ARD.…”

Section: Introductionmentioning

confidence: 99%

Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases

Imamura

Mukaino

Takamatsu

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Autonomic neuropathy has been reported in autoimmune rheumatic diseases (ARD) including Sjögren’s syndrome, systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathophysiological mechanism underlying autonomic dysfunction remains unknown to researchers. On the other hand, autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder, which causes dysautonomia that is mediated by autoantibodies against ganglionic acetylcholine receptors (gAChRs). The purpose of this review was to describe the characteristics of autonomic disturbance through previous case reports and the functional tests used in these studies and address the importance of anti-gAChR antibodies. We have established luciferase immunoprecipitation systems to detect antibodies against gAChR in the past and determined the prevalence of gAChR antibodies in various autoimmune diseases including AAG and rheumatic diseases. Autonomic dysfunction, which affects lower parasympathetic and higher sympathetic activity, is usually observed in ARD. The anti-gAChR antibodies may play a crucial role in autonomic dysfunction observed in ARD. Further studies are necessary to determine whether anti-gAChR antibody levels are correlated with the severity of autonomic dysfunction in ARD.

show abstract

“…Neurological complications occur in 15 to more than 35% of patients with pSS [81][82][83][84][85][86] and may occur as a presenting feature or during the course of the disease. 31,87,88 Peripheral neuropathy is most common, 79,83,84,86,[88][89][90][91] but other neurological manifestations include mononeuritis multiplex 83 ; small fiber neuropathy 82,85,92,93 ; autonomic neuropathy 94 ; sensory ataxic neuropathy 88,95 ; ganglionopathy 85 ; transverse myelitis 85,96 ; neuromyelitis optica 81,97,98 ; optic neuritis 96 ; multiple sclerosis-like disease 99,100 ; cranial neuropathies 31,95,100 ; seizures 100 ; headaches 101,102 ; cognitive deficits 100,101 ; and mood disorders. 101 Cerebellar degeneration, 99,100,103,104 hemiparesis secondary to bila...…”

Section: Neurological Involvementmentioning

confidence: 99%

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

Chung

Wilgus

Fishbein

et al. 2019

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by mononuclear cells (principally lymphocytes) infiltrating exocrine glands (e.g., salivary and lacrimal glands), leading to destruction of exocrine epithelial cells and dryness of mucosal surfaces. Cardinal symptoms are dry eyes (xerophthalmia) and dry mouth (xerostomia). Extraglandular sites are affected in 30 to 40% of cases of SS (particularly neurological, kidneys, skin, and lungs). B cell hyperactivity, autoantibody production, and hypergammaglobulinemia are cardinal features of SS. Primary SS is not associated with other autoimmune diseases. However, SS can complicate diverse autoimmune disorders (particularly systemic lupus erythematosus, rheumatoid arthritis, and scleroderma); this form is termed “secondary SS.” Pulmonary involvement is usually not a dominant feature of SS, but may be severe in some cases. In this review, we discuss specific tracheal, bronchiolar, and pulmonary complications of SS including xerotrachea, bronchiolitis, bronchiectasis, interstitial lung disease, nonspecific interstitial pneumonia, usual interstitial pneumonia, lymphoid interstitial pneumonia, organizing pneumonia, acute fibrinous and organizing pneumonia, pulmonary cysts, pleural effusions, pulmonary amyloidosis, and bronchus- or lung-associated lymphomas.

show abstract

Insights from the ganglionic acetylcholine receptor autoantibodies in patients with Sjögren’s syndrome

Abstract: The present results suggest the possibility of anti-gAChR antibodies aiding the diagnostics of SS with autonomic dysfunction.

Cited by 31 publications

References 37 publications

Autoimmune autonomic ganglionopathy associated with Sjögren’s syndrome presenting with recurrent abdominal distension

Autoimmune autonomic ganglionopathy associated with Sjögren’s syndrome presenting with recurrent abdominal distension

Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

Contact Info

Product

Resources

About