Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets

Li, Mei; Yin, Xin; Guan, Lizheng; Zhang, Xia; Li, Tao; Cui, Pengfei; Ma, Yong; Hou, Yujie; Shi, Jianzhong; Chen, Hualan

doi:10.1007/s11427-019-9522-7

Cited by 17 publications

(10 citation statements)

References 12 publications

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“…Sixth, billions of birds are sold annually via live bird markets (LBMs) in China because many Chinese believe that the birds in LBMs are safer and more delicious (our unpublished data). This adds fuel to the fire of AIV because LBMs are hubs for viral aggregation, replication, re-assortment, mutation, spread and human infection (Li et al, 2019;Su et al, 2015;Yu et al, 2014). Seventh, billions of birds are transported from poultry farms to LBMs, and transportation can transmit AIV to distant poultry farms via vehicles and personnel if appropriate biosecurity protocols are not followed (Lu, Leigh Brown, & Lycett, 2017).…”

mentioning

confidence: 99%

Control of avian influenza in China: Strategies and lessons

Liu

Zhuang

Wang

et al. 2020

Transbound Emerg Dis

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These AIV subtypes could spark a human pandemic once adapted through mutation. Why have they persisted in China? How have they been circulating in China? What strategies have been implemented in China to control the spread of AIV? How scientific and effective are these strategies? What lessons can we learn from the experience in China for the control of AIV? We attempted to answer these questions in this review based on relevant studies in the literature and our unpublished surveillance data collected over a 12-year period from 2007 to 2018 (Tables 1 and 2), with the aim to provide insights to improve guidelines for the control of AIV, both in China and globally. 2 | ROOTS OF THE PROB LEMS The prevalence of AIV in China is rooted in its ingrained ecosystem and socioeconomic features. First, billions of wild birds come into contact with domestic birds, either directly or indirectly,

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mentioning

confidence: 99%

Control of avian influenza in China: Strategies and lessons

Liu

Zhuang

Wang

et al. 2020

Transbound Emerg Dis

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“…For example, vaccination in poultry from 2017 has successfully prevented the prevalence of the H7N9 influenza virus in China and eradicated human infection with the H7N9 virus [ 46–48 ]. However, a previous study indicated that up to 57% of the chickens with high HI antibody titer (mean titer was 7.8 log 2 ) were infected with the H9N2 virus within five days of being transferred to the LBM [ 49 ]. Although the chickens were well vaccinated with H9N2 vaccines, the chickens were not completely protected from H9N2 virus infection in the LBM.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization, receptor binding property, and replication in chickens and mice of H9N2 avian influenza viruses isolated from chickens, peafowls, and wild birds in eastern China

Guo

Wang

Zhao

et al. 2021

Emerging Microbes & Infections

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“…Previous studies indicate that H9N2 influenza viruses provided their internal genes to the H7N9 and H10N8 viruses that have caused human infections in China [27,28]. Given that the H9N2 viruses are actively circulating in the live poultry markets [4,29], the H3N2 avian influenza viruses may also acquire the internal genes from the H9N2 viruses and adapt in domestic poultry or even “jump” to humans.…”

Section: Discussionmentioning

confidence: 99%

H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets

Guan

Shi

Kong

et al. 2019

Emerging Microbes & Infections

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The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also commonly found in animals. If a different lineage of H3N2 virus jumps to humans, a human influenza pandemic could occur with devastating consequences. Here, we studied the genetics, receptor-binding properties, and replication and transmission in mammals of 15 H3N2 avian influenza viruses detected in live poultry markets in China. We found that the H3N2 avian influenza viruses are complicated reassortants with distinct replication phenotypes in mice. Five viruses replicated efficiently in mice and bound to both human-type and avian-type receptors. These viruses transmitted efficiently to direct-contact guinea pigs, and three of them also transmitted among guinea pigs and ferrets via respiratory droplets. Moreover, ferret antiserum induced by human H3N2 viruses did not react with any of the H3N2 avian influenza viruses. Our study demonstrates that the H3N2 avian influenza viruses pose a clear threat to human health and emphasizes the need for continued surveillance and evaluation of the H3N2 influenza viruses circulating in nature.

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Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets

Cited by 17 publications

References 12 publications

Control of avian influenza in China: Strategies and lessons

Control of avian influenza in China: Strategies and lessons

Molecular characterization, receptor binding property, and replication in chickens and mice of H9N2 avian influenza viruses isolated from chickens, peafowls, and wild birds in eastern China

H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets

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