2014
DOI: 10.4236/ojst.2014.42013
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Insights and relative effect of aspirin, naproxen and ibuprofen containing hydrogels: From design to performance as a functional dual capacity restorative material and build in free radical defense: <i>In-vitro</i> studies

Abstract: Restorative materials in the new era aim to be "bioactive" and long-lasting. It has been suggested that the anti-inflammatory activity of some non-steroidal anti-inflammatory drugs (NSAIDs) may be partly due to their ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to inhibit the respiratory burst of neutrophils triggered by various activating agents. As a part of our continuous interest of developing functional dual action restorative materials capable of being… Show more

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Cited by 11 publications
(12 citation statements)
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“…The therapeutic agent (naproxen, ibuprofen or aspirin) containing gel was prepared by dispersion of naproxen powder 0.4 gm in glycerol (5% w/w) using a mortar and a pestle following the earlier reported generic protocol [27]. Ten milliliters of glacial acetic acid (3% w/w) was then added with continuous mixing and finally chitosan:vitamin C polymer was spread on the surface of the dispersion and mixed well to form the required gel.…”
Section: Preparation Of Various Chitosan:vitamin C Hydrogels Gels: Gementioning
confidence: 99%
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“…The therapeutic agent (naproxen, ibuprofen or aspirin) containing gel was prepared by dispersion of naproxen powder 0.4 gm in glycerol (5% w/w) using a mortar and a pestle following the earlier reported generic protocol [27]. Ten milliliters of glacial acetic acid (3% w/w) was then added with continuous mixing and finally chitosan:vitamin C polymer was spread on the surface of the dispersion and mixed well to form the required gel.…”
Section: Preparation Of Various Chitosan:vitamin C Hydrogels Gels: Gementioning
confidence: 99%
“…Spectrophotometer (Cintra 5, GBC Scientific equipment, Australia) at λ max 275 nm (aspirin), λ max 264 nm (for ibuprofen), and λ max 260 nm (for naproxen) [26]. Each sample was replaced by the same volume of phosphate buffer pH 6.8 to maintain its constant volume and sink condition [27]. Table 1.…”
Section: In Vitro Study Of Therapeutic Agent Release Profile: Generalmentioning
confidence: 99%
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