Insights about stabilization of sulforaphane through microencapsulation

Zambrano, Víctor; Bustos, Rubén; Mahn, Andrea

doi:10.1016/j.heliyon.2019.e02951

Cited by 28 publications

(29 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its direct administration has been limited because of the instability of SFN. Some research about SFN stabilization is being conducted [ 9 ]. Another way to administer SFN to humans is through broccoli sprout extracts or minimally processed broccoli.…”

Section: Introductionmentioning

confidence: 99%

Potential of Sulforaphane as a Natural Immune System Enhancer: A Review

Mahn

Castillo

2021

Molecules

Self Cite

View full text Add to dashboard Cite

Brassicaceae are an outstanding source of bioactive compounds such as ascorbic acid, polyphenols, essential minerals, isothiocyanates and their precursors, glucosinolates (GSL). Recently, GSL gained great attention because of the health promoting properties of their hydrolysis products: isothiocyanates. Among them, sulforaphane (SFN) became the most attractive one owing to its remarkable health-promoting properties. SFN may prevent different types of cancer and has the ability to improve hypertensive states, to prevent type 2 diabetes–induced cardiomyopathy, and to protect against gastric ulcer. SFN may also help in schizophrenia treatment, and recently it was proposed that SFN has potential to help those who struggle with obesity. The mechanism underlying the health-promoting effect of SFN relates to its indirect action at cellular level by inducing antioxidant and Phase II detoxifying enzymes through the activation of transcription nuclear factor (erythroid-derived 2)-like (Nrf2). The effect of SFN on immune response is generating scientific interest, because of its bioavailability, which is much higher than other phytochemicals, and its capacity to induce Nrf2 target genes. Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail. This article provides a revision about the relationship between sulforaphane and immune response in different diseases. Special attention is given to clinical trials related with immune system disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Potential of Sulforaphane as a Natural Immune System Enhancer: A Review

Mahn

Castillo

2021

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…An option to stabilise PEITC and even increase its bioavailability in a food matrix is micro/nanoencapsulation. However, PEITC and ITCs micro/nanoencapsulation has been poorly studied [47]. Till now, cyclodextrin was reported as a plausible carrier for ITCs [48].…”

Section: Future Perspectivesmentioning

confidence: 99%

Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

Coscueta¹,

Sousa²,

Reis³

et al. 2021

Preprint

View full text Add to dashboard Cite

The incidence of gastrointestinal diseases (cancer in particular) has increased progressively with considerable morbidity, mortality, and a high economic impact on the healthcare system. Dietary intake of natural bioactive phytochemicals showed to have cancer-preventing and therapeutic effects. This includes the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC), a bioactive compound from watercress. PEITC antioxidant, anti-inflammatory and anti-cancer properties are of particular importance. This review summarizes the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discuss the safe and recommended dose of PEITC. Besides, we establish a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural nutraceutical for industrial use. This is a topic that still needs more scientific development, but with the potential to lead to a viable strategy in the prevention of cancer and other associated diseases of the gastrointestinal tract.

show abstract

“…Microencapsulation is a strategy that has rarely been addressed as a way of administering PEITC or any ITCs [12]. Dharmala et al developed a microparticle using stearic acid and chitosan to deliver PEITC, based on Solid Lipid Nanoparticle methodology.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, methods of administration of bioactive compounds are increasingly sought in a selective, non-invasive way and with minimal side effects. Hence, microencapsulation is a technology used to improve the delivery strategy, promoting the controlled release and protect bioactive compounds, preserving their properties from undesirable reactions, while improving their functionality and bioavailability [12,13]. Additionally, polymeric microparticles gained significant importance as they are biodegradable, biocompatible and can be formulated using a sustainable approach [14].…”

Section: Introductionmentioning

confidence: 99%

“…According to the few studies of microencapsulated ITCs, some methods seem more promising, mainly ionic gelation and complex coacervation. Both methods used chitosan, though are underexplored until now [12]. Currently, there is no study about the encapsulation of PEITC (or any ITCs), using chitosan and a liquid lipid, which opens a relevant research line aiming at identifying microparticles as delivery systems for bioactive compounds with potential use in biomedical and nutraceutical fields.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: optimal formulation

Coscueta

Sousa

Reis

et al. 2021

Preprint

View full text Add to dashboard Cite

Phenylethyl isothiocyanate (PEITC), a chemopreventive compound, is highly reactive due to its considerably electrophilic nature. Furthermore, it is hydrophobic and has low stability, bioavailability and bioaccessibility, restricting its use in biomedical and nutraceutical or food applications. Thus, the encapsulation of this agent has the function of overcoming these limitations, promoting its solubility in water, and stabilizing it, preserving its bioactivity. So, polymeric microparticles were developed using chitosan-olive oil-PEITC systems. For this, an optimisation process (factors: olive oil: chitosan ratio and PEITC: chitosan ratio) were implemented through a central composite design. The responses were: the particle size, zeta-potential, polydisperse index, and entrapment efficiency. The optimal formulation was further characterized by FTIR and biocompatibility in Caco-2 cells. Optimal conditions were olive oil: chitosan and PEITC: chitosan ratios of 1.46 and 0.25, respectively. These microparticles had a size of 629 nm, a zeta-potential of 32.3 mV, a polydispersity index of 0.329, and an entrapment efficiency of 98.49%. We found that the inclusion process affected the optical behaviour of the PEITC, as well as the microparticles themselves and their interaction with the medium. Furthermore, the microparticles did not show cytotoxicity within the therapeutic values of PEITC. Thus, PEITC was microencapsulated with characteristics suitable for potential biomedical, nutraceutical and food applications.

show abstract

Insights about stabilization of sulforaphane through microencapsulation

Cited by 28 publications

References 40 publications

Potential of Sulforaphane as a Natural Immune System Enhancer: A Review

Potential of Sulforaphane as a Natural Immune System Enhancer: A Review

Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: optimal formulation

Contact Info

Product

Resources

About