Insight on the Mechanism of the Effects of Hydrochlorothiazide on Nocturnal Enuresis

Park, Se Jin; Kim, Ji Eun; Smıth, Lee

doi:10.1159/000316105

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…Jang et al in a study showed that the impact of HCT, which induced hypocalciuria in hypercalciuric rats, was associated with increased expression of transient receptor potential vanilloid 5 (TRPV5) protein; TRPV5 may also have a significant effect on the regulation of calcium excretion from the urinary system (22). Mechanisms of the relationship between HCT and NE explained by Park et al (23) confirmed the current study results. Porter et al reported that due to low cost, ease of use, easy to access, and low side effects of HCT, HCT can be used as an effective drug to treat NE in children (24).…”

Section: Discussionsupporting

confidence: 87%

Therapeutic Efficacy of Hydrochlorothiazide in the Primary Monosymptomatic Nocturnal Enuresis of Children

et al. 2017

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Background: Nocturnal enuresis is a symptom with probably multiple etiologic factors and a high prevalence. Conventional therapies is expensive and complicated, since the effect of calcium on voiding dysfunction was approved. Therefore, to the current study aimed at evaluating the therapeutic effect of hydrochlorothiazide on primary monosymptomatic nocturnal enuresis (PMNE). Methods: The current study was conducted based on the interviews with patients. Morning urine test was evaluated in children with PMNE detection and specific gravity < 1010 enrolled to the study (110 children comprised of 57 cases and 53 controls). Children were divided into 2 groups; in the case group, hydrochlorothiazide (tablet 1 mg/kg and maximum 50 mg) was administered in the morning and the control group was only given necessary training about enuresis. For 3 times and with 1 month interval (based on a predetermined questionnaire) the frequency of nocturnal enuresis was checked. Data were transferred into SPSS program and the therapeutic effect of hydrochlorothiazide on primary monosymptomatic nocturnal enuresis was investigated. Findings: There was a statistically significant difference regarding the frequency of nocturnal enuresis between the 2 groups (P = 0.0001). Also, both groups were matched by age (P = 899) and gender (P = 607). Conclusions: Hydrochlorothiazide can be used as an effective and safe therapeutic option for treatment of primary monosymptomatic nocturnal enuresis.

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Section: Discussionsupporting

confidence: 87%

Therapeutic Efficacy of Hydrochlorothiazide in the Primary Monosymptomatic Nocturnal Enuresis of Children

et al. 2017

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“…Park et al ( 14 ), in a letter to the editor, in 2010, described two hypotheses concerning the relationship between hypercalciuria and NE and the possible effect of HCT on NE treatment: 1) Based on the evidence, transient receptor potential vanilloid 5 (TRPV5), which is in the distal convoluted tubule of the kidney, may have a significant role in the regulation of urinary calcium excretion ( 18 ). Also, the down-regulation of TRPV5 reduces reabsorption of calcium and becomes a factor for urinary calcium loss and causes hypercalciuria ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…Jang et al ( 18 ) showed that in hypercalciuric rats, the hypocalciuric impact of HCT is associated with increased expression of TRPV5 protein. 2) HCT may have a role in the expression of aquaporin-2 (AQP2) and major renal Na + transporters ( 14 ). Kim et al ( 20 ) demonstrated that HCT reduces urinary output and increases urine osmolality by increasing the expression of AQP2, thiazide-sensitive NaCl cotransporter and α-epithelial sodium channel in lithium-induced nephrogenic diabetes insipidus in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Kim et al ( 20 ) demonstrated that HCT reduces urinary output and increases urine osmolality by increasing the expression of AQP2, thiazide-sensitive NaCl cotransporter and α-epithelial sodium channel in lithium-induced nephrogenic diabetes insipidus in rats. Although these relationships have not been investigated in children with NE, it seems that the up-regulation of AQP2 and distal renal Na + transporters in response to HCT may indicate a role of HCT in the treatment of NE ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…Since idiopathic hypercalciuria can be one of the causes of voiding dysfunctions such as NE ( 8 - 11 , 14 ) and Hydrochlorothiazide (HCT) significantly ameliorates hypercalciuria, it was suggested that HCT may be helpful in the treatment of NE ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Efficacy of Hydrochlorothiazide in Primary Monosymptomatic Nocturnal Enuresis in Boys With Idiopathic Hypercalciuria

et al. 2015

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Background:Idiopathic hypercalciuria (IHC) can be one of the causes of nocturnal enuresis (NE) and hydrochlorothiazide (HCT) ameliorates hypercalciuria.Objectives:The aim of this study was to assess the therapeutic efficacy of HCT in boys with primary monosymptomatic NE (PMNE).Patients and Methods:This study was a randomized double-blind placebo-controlled clinical trial. A hundred boys with PMNE and IHC were randomly assigned into two groups of experimental (treated with HCT 1 mg/kg/day) and control and all patients were followed for 4 months for the number of wet-night episodes.Results:The mean numbers of wet-night episodes in the first (intervention: 8.34 ± 8.54, control: 9.1 ± 9.3, P = 0.3), second (7.1 ± 7.3, 7.9 ± 8.1, P = 0.4), third (7.8 ± 8, 7.9 ± 8.1, P = 0.1) and fourth (4.9 ± 5.1, 5.9 ± 6, P = 0.3) months were not significantly different between the two groups. However, the decrease in the average wet-night episodes during the 4 months of treatment in the intervention group (P = 0.019) unlike the control group. Not more significant compared to control group (P = 0.191). All patients who were treated by HCT became normocalciuric. However, in 21 patients the dose was increased to 2 mg/kg/day.Conclusions:Single daily dose of HCT is a safe and effective therapeutic option in the treatment of PMNE in children with IHC.

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Alarm interventions for nocturnal enuresis in children

Codarini

Stewart

Hahn

et al. 2020

Cochrane Database of Systematic Reviews

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Insight on the Mechanism of the Effects of Hydrochlorothiazide on Nocturnal Enuresis

Cited by 3 publications

References 5 publications

Therapeutic Efficacy of Hydrochlorothiazide in the Primary Monosymptomatic Nocturnal Enuresis of Children

Therapeutic Efficacy of Hydrochlorothiazide in the Primary Monosymptomatic Nocturnal Enuresis of Children

Therapeutic Efficacy of Hydrochlorothiazide in Primary Monosymptomatic Nocturnal Enuresis in Boys With Idiopathic Hypercalciuria

Alarm interventions for nocturnal enuresis in children

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