Insight on the chelation of aluminum(III) and iron(III) by curcumin in aqueous solution

Beneduci, Amerigo; Corrente, Giuseppina Anna; Marino, Tiziana; Aiello, Donatella; Bartella, Lucia; Donna, Leonardo Di; Napoli, Anna; Russo, Nino; Romeo, Isabella; Furia, Emilia

doi:10.1016/j.molliq.2019.111805

Cited by 38 publications

(19 citation statements)

References 49 publications

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“…It is a bis-α,β-unsaturated β-diketone and exists in different tautomeric forms (see Figure 9). The β-diketone form prevails in acidic and neutral aqueous solutions, while the enol form predominates in more alkaline media [53]. In the case of curcumin, the aromatic rings are functionalized with hydroxy and methoxy groups, whereas the other curcuminoids lack one or both methoxy groups (desmethoxycurcumin and bisdesmethoxycurcumin, respectively).…”

Section: Chemistrymentioning

confidence: 99%

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

et al. 2019

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Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well-known capability of these molecules to act as antioxidants, they are able to interact with cell-signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.

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Section: Chemistrymentioning

confidence: 99%

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

et al. 2019

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“…The sodium hydroxide titrant solutions, the hydrochloric acid, the sodium chloride and the metal cations chloride stock solutions were prepared and standardized as previously described. [14] All solutions were prepared with bidistilled water. The titrations were carried out with the same apparatus described previously.…”

Section: Potentiometric and Spectrophotometric Detailsmentioning

confidence: 99%

“…The chelating agents actually in use belong to few chemical categories (i. e., poliaminocarboxylic acids; ligands containing mercapto groups; ligands with oxygen coordinating groups and dithiocarbamates). In our continuous effort to identify selective chelators towards bioavailable and toxic metal ions, [11][12][13][14] in the present work the attention was focused on the recently proposed N,O synthetic chelator 1 reported in Scheme 1. [15] The authors showed that the novel proposed chelator 1 exhibits specific Cu(II) selectivity at physiological pH alleviating metal overload induced oxidative stress and assessed the stability of the formed copper complexes over time.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sequestering Ability of a Synthetic Chelating Agent towards Copper(II) and Iron(III): A Detailed Theoretical and Experimental Analysis

Ritacca

Malacaria

Algieri

et al. 2020

Chemistry An Asian Journal

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In the continuous effort to identify selective chelators towards bioavailable and toxic metal ions, the potential selectivity of a novel N,O chelating ligand, recently synthesized and claimed to be able to bind to Cu(II) ions forming stable complexes while leaving unaltered the level of essential metal ions, was scrutinized using a combined theoretical and experimental approach. A multistep synthetic procedure was used to synthesize the ligand, whose chelating properties along with the stability of the complexes formed binding Cu(II) and, for comparison, Fe(III) ions were evaluated using potentiometric measurements and UV-Vis spectroscopy. DFT analysis allowed to disclose the structural characteristics of the formed complexes. In the plethora of all the possible structures, a selection of the most reliable ones was achieved by means of a stringent comparison between experimental and simulated UV-Vis spectra. The outcomes of the present investigation demonstrate that the Cu(II) sequestering ability of the ligand is smaller than that towards Fe(III). The strategy used here should allow to check the propensity of ligands in selectively binding metal ions.

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“…The strong chelating ability of diketones has been widely investigated toward some metal ions, depending on the molar ratio between metal ions and curcumin, the solvent, the metal salt, and the pH media. Over the past few decades, several studies have been published dealing with metal curcumin complexes and their applications [ 40 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights

et al. 2021

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This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite the contributions of previous studies on the chemical properties and biological activity of these metal complexes involving such natural antioxidants, further detailed relationships between the structure and properties are still required. In this context, the investigation on the coordination properties of Al(III) and Fe(III) toward these natural antioxidant molecules might deserve high interest to design water soluble molecule-based metal carriers that can improve the metal’s intake and/or its removal in living organisms.

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Insight on the chelation of aluminum(III) and iron(III) by curcumin in aqueous solution

Cited by 38 publications

References 49 publications

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Sequestering Ability of a Synthetic Chelating Agent towards Copper(II) and Iron(III): A Detailed Theoretical and Experimental Analysis

A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights

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