Insight on immune cells in rejection and infection postlung transplant

Liao, Mingfeng; Wang, Chaoxi; Zhang, Mingxia; Qiao, Kun

doi:10.1002/iid3.868

Cited by 2 publications

References 63 publications

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Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Puniya

Moore

Mohammed

et al. 2020

Preprint

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The human immune system, which protects against pathogens and diseases, is a complex network of cells and molecules. The effects of complex dynamical interactions of pathogens and immune cells on the immune response can be studied using computational models. However, a model of the entire immune system is still lacking. Here, we developed a comprehensive computational model that integrates innate and adaptive immune cells, cytokines, immunoglobulins, and nine common pathogens from different classes of virus, bacteria, parasites, and fungi. This model was used to investigate the dynamics of the immune system under two scenarios: (1) single infection with pathogens, and (2) various medically relevant pathogen coinfections. In coinfections, we found that the order of infecting pathogens has a significant impact on the dynamics of cytokines and immunoglobulins. Thus, our model provides a tool to simulate immune responses under different dosage of pathogens and their combinations, which can be further extended and used as a tool for drug discovery and immunotherapy. Furthermore, the model provides a comprehensive and simulatable blueprint of the human immune system as a result of the synthesis of the vast knowledge about the network-like interactions of various components of the system.

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Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Puniya

Moore

Mohammed

et al. 2020

Preprint

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Lung transplantation models for preclinical trial (literature review)

Bunenkov,

Akopov,

Popov

et al. 2024

RJTAO

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Lung transplantation (LT) is the only treatment for many end-stage lung diseases. Despite significant progress in transplantology and surgery, LT remains a high-tech surgical procedure performed at select research centers. Primary graft dysfunction, acute rejection, and chronic lung allograft dysfunction are serious problems that can worsen lung transplant outcomes significantly. Using animal models in experimental studies to investigate these pathologic conditions is one of the more rational approaches. A literature review was conducted in order to select a suitable model that reproduces pathologic processes developing after LT. The literature was searched and ana- lyzed in MEDLINE and Elibrary databases, and the US National Institute of Health guidelines for the period up to December 2023 were reviewed. It was found that the most frequently used models are small laboratory animal models (without LT) and large animal models (with LT).

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Insight on immune cells in rejection and infection postlung transplant

Cited by 2 publications

References 63 publications

Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Lung transplantation models for preclinical trial (literature review)

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