Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia

Rossell, Susan L.; Coakes, Julia; Shapleske, Jane; Woodruff, Peter; David, Anthony S.

doi:10.1017/s0033291702006803

Cited by 135 publications

(94 citation statements)

References 52 publications

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“…Recent studies have compared high and low insight groups amongst individuals with schizophrenia and found particular abnormalities and functioning in low insight groups [70,71]. Nonetheless, even with the positive findings cited above, caution must be exercised as there have been other studies that call into question such associations due to negative findings [72,73].…”

Section: Neurocognition and Anomalous Brain Structure And Functionmentioning

confidence: 97%

An integrative model of the impairments in insight in schizophrenia: emerging research on causal factors and treatments

Vohs

George

Leonhardt

et al. 2016

Expert Review of Neurotherapeutics

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Introduction: Poor insight, or unawareness of some major aspect of mental illness, is a major barrier to wellness when it interferes with persons seeking out treatment or forming their own understanding of the challenges they face. One barrier to addressing impaired insight is the absence of a comprehensive model of how poor insight develops. Areas covered: To explore this issue we review how poor insight is the result of multiple phenomena which interfere with the construction of narrative accounts of psychiatric challenges, rather than a single social or biological cause.Expert Commentary: We propose an integrative model of poor insight in schizophrenia which involves the interaction of symptoms, deficits in neurocognition, social cognition, metacognition, and stigma. Emerging treatments for poor insight including therapies which focus on the development of metacognition are discussed.

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Section: Neurocognition and Anomalous Brain Structure And Functionmentioning

confidence: 97%

An integrative model of the impairments in insight in schizophrenia: emerging research on causal factors and treatments

Vohs

George

Leonhardt

et al. 2016

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

show abstract

“…Despite these positive findings, some studies have failed to identify potential neural substrates associated with insight [118][119][120] . A number of methodological factors could contribute to these mixed findings, including inconsistent definitions of insight, varying instruments used to measure insight, and heterogeneous sample characteristics.…”

Section: Abnormalities In Brain Function As a Root Of Poor Insightmentioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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“…However, many questions regarding how deficits in executive functions lead to poor insight, as well as the implication of other cognitive functions need clarification. As for structural neuroimaging research, associations of insight with prefrontal cortex have been revealed in most studies Flashman et al, 2000;, Shad et al, 2004Sapara et al, 2007), with some exceptions (Rossell et al, 2003). Again, further research is needed to further specify the neurobiological basis of poor insight.…”

Section: Models Of Poor Insight In Psychosismentioning

confidence: 99%

Exploratory Study of the Association Between Insight and Theory of Mind (Tom) in Stable Schizophrenia Patients

Pousa¹,

Duñó²,

Navarro³

et al. 2008

Schizophrenia Research

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Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia

Cited by 135 publications

References 52 publications

An integrative model of the impairments in insight in schizophrenia: emerging research on causal factors and treatments

An integrative model of the impairments in insight in schizophrenia: emerging research on causal factors and treatments

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Exploratory Study of the Association Between Insight and Theory of Mind (Tom) in Stable Schizophrenia Patients

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