Insight into the Role of Psychological Factors in Oral Mucosa Diseases

Guo, Yuexin; Wang, Boya; Gao, Han; He, Chengwei; Hua, Rongxuan; Gao, Lei; Du, Yixuan; Xu, Jingdong

doi:10.3390/ijms23094760

Cited by 5 publications

(4 citation statements)

References 119 publications

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“…Серед захворювань СОПР психосоматичного генезу значне місце займають червоний плоский лишай [11,15], хронічний рецидивуючий афтозний стоматит [2,3,15], глосодинія [4,8,12], ексфоліативний хейліт [5,14], новоутворення [9] тощо. Більшість захворювань СОПР виникає та рецидивує на тлі загострення соматичної патології у поєднанні з порушенням психоемоційного стану пацієнтів, але, на превеликий жаль, лікарі-стоматологи не надають належ-ної уваги психологічному стану таких пацієнтів і не проводять необхідної корекції [6]. Найчастіше при обстеженні хворих особливу увагу звертають на скарги, анамнез захворювання, соматичну патологію, особливості перебігу захворювання, але не враховують інтенсивність стресового чинника, його тривалість та повторюваність, який може бути одним з основних факторів ризику у розвитку захворювань порожнини рота [13].…”

Section: вступunclassified

The psychoemotional state of patients with oral mucosal diseases and the effectiveness of its correction

Мунтян¹,

Гаджула²,

Muntian³

et al. 2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The work aims to study the psychoemotional state of patients with oral mucosal diseases and to evaluate the effectiveness of oral pathology treatment combined with psychological disorder management. Evaluation of the psychoemotional state of 48 patients with oral mucosal diseases was carried out using the Hospital Anxiety and Depression Scale (HADS). The assessment showed subclinical (mild) and clinically expressed (moderate) anxiety, as well as mild and moderate depression in pre-treatment patients. Based on the type of management, patients were divided into the main and comparison groups. The psychoemotional state of the patients of the main group was analyzed, and comprehensive treatment of oral mucosal diseases was administered, enhanced by psychological management. Patients of the comparison group underwent complex treatment of dental diseases with no psychological management. Statistical processing of the research results was carried out using generally accepted methods of variation statistics with the determination of the Student’s t-test and computer programs: “Statistica 6.1”, Microsoft® Excel 2017. Differences between the groups were considered statistically significant at p<0.05. The results of the study suggest that psychoemotional disorders lead to the development of oral mucosal diseases; at the same time, these oral diseases increase anxiety and depression. Hence, the treatment of patients suffering from oral mucosal diseases requires psychological management. After treatment, patients of the main group showed improved psychoemotional state and decreased clinical manifestations of oral mucosal diseases sooner than patients of the comparison group. Positive results of improving the psychoemotional state of patients with dental pathology invite inquiry into further study and improvement of the management strategies.

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Section: вступunclassified

The psychoemotional state of patients with oral mucosal diseases and the effectiveness of its correction

Мунтян¹,

Гаджула²,

Muntian³

et al. 2023

Rep. of Vinnytsia Nation. Med. Univ.

View full text Add to dashboard Cite

show abstract

“…Oral mucosal diseases are not only related to local mucosal damage, but also to systemic diseases, and they may be aggravated or induced by anxiety, depression, and stress. 1 Oral mucosal diseases may be a direct manifestation of negative emotions or an indirect result of psychological abnormalities, 2 but their psychosomatic causes have not been comprehensively clarified. There are few studies on the relationship between oral mucosal diseases, negative emotions, and potential pathogeneses, and due to contradicting research conclusions, the relationship between them is controversial.…”

Section: Introductionmentioning

confidence: 99%

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Zhou,

Lin

2023

J Int Med Res

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The aetiology of oral mucosal diseases, such as recurrent aphthous ulcer (RAU), oral lichen planus (OLP) and burning mouth syndrome (BMS), involves many factors, and it remains difficult for clinicians to effectively relieve disease symptoms and formulate coping strategies. With the rapid development of psychology, the role of mental and psychological factors in RAU, OLP and BMS has gradually attracted researchers attention, but the specific mechanism has not been completely determined. This narrative review describes the potential neurobiological mechanism of oral mucosal diseases and detailed psychological factors after introducing relevant research into psychological factors and oral mucosal diseases. Future research strategies and innovations needed to understand and treat oral mucosal diseases and psychological factors, as well as how to prevent oral mucosal diseases by regulation of the neuroendocrine system, are also discussed.

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“…Meanwhile, current evidence suggests that bad mental attitudes are not conducive to the prognosis of oral disease ( 10 ), while inflammatory mediators were found to be increased locally in the tumors of stressed rats ( 11 ). Moreover, it has been found that the expression of neurotransmitters was elevated in saliva and serum of patients with burning mouth syndrome with mood disorders ( 12 ). Although significant emphasis has been placed on the interaction between stress-related factors and oral diseases, few studies have investigated the potential molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics analysis reveals the effects of microbiota on oral homeostasis

Long

et al. 2022

Front. Immunol.

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The oral epithelium’s normal morphological structure and function play an important role in maintaining oral homeostasis, among which microbiota and chronic stress are key contributing factors. However, the effects of microbiota and chronic stress on the morphological structures and molecular function of oral homeostasis remain unclear. In this study, morphological staining was used to compare the tongue structure of specific pathogen-free and germ-free mice, and an integrated multi-omics analysis based on transcriptomics, proteomics, and metabolomics was performed to investigate the regulatory mechanisms of microbiota and chronic stress on oral homeostasis. We found that the morphological structure of the tongue in germ-free mice was disordered compared with in specific pathogen-free mice, especially in the epithelium. Multi-omics analysis indicated that differentially expressed molecules of the tongue between germ-free and specific pathogen-free mice were significantly enriched in the mitochondrial metabolic process and immune response. Interestingly, microbiota also significantly influenced the permeability of the oral epithelial barrier, represented by the differential expression of keratinization, and cell adhesion molecules. It was worth noting that the above changes in the tongue between specific pathogen-free and germ-free mice were more significant after chronic stress. Collectively, this is the first study to reveal that the microbiota might maintain oral homeostasis by reshaping the structure of the oral epithelial barrier and changing the function of molecular biology, a process that may be driven by the immune response and mitochondrial metabolic process of oral tissue. Furthermore, chronic stress can enhance the regulatory effects of microbiota on oral homeostasis.

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Insight into the Role of Psychological Factors in Oral Mucosa Diseases

Cited by 5 publications

References 119 publications

The psychoemotional state of patients with oral mucosal diseases and the effectiveness of its correction

The psychoemotional state of patients with oral mucosal diseases and the effectiveness of its correction

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Multi-omics analysis reveals the effects of microbiota on oral homeostasis

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