Insight into the Relationship of Aqueous Solubility and Single-Crystal Structure of Harmine’s New Organic Salt Forms
Minghuang Hong,
Nan Wu,
Qinglin Wang
et al.
Abstract:Harmine (HAM) is a natural product with neuroprotective and antitumor activity. Its poor aqueous solubility is the major factor limiting its clinical application. In this work, seven new organic acid salts of HAM were prepared and systematically characterized. Their single crystals were obtained, and the structures were identified by a single-crystal X-ray diffractometer. The corresponding solubilities in water were determined in the temperature range of 20−35 °C by the HPLC method. All HAM salts showed signif… Show more
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