Insight into the mechanism of gallstone disease by proteomic and metaproteomic characterization of human bile
Xue-Ting Yang,
Jie Wang,
Ying-Hua Jiang
et al.
Abstract:IntroductionCholesterol gallstone disease is a prevalent condition that has a significant economic impact. However, the role of the bile microbiome in its development and the host’s responses to it remain poorly understood.MethodsIn this study, we conducted a comprehensive analysis of microbial and human bile proteins in 40 individuals with either gallstone disease or gallbladder polyps. We employed a combined proteomic and metaproteomic approach, as well as meta-taxonomic analysis, functional pathway enrichme… Show more
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