Insight into the interaction between tannin acid and bovine serum albumin from a spectroscopic and molecular docking perspective

Xu, Wei; Ning, Yuli; Cao, Shiwan; Wu, Guanchen; Sun, Haomin; Chai, Liwen; Wu, Shuping; Li, Jingyi; Luo, Denglin

doi:10.1039/d3ra00375b

Cited by 5 publications

(2 citation statements)

References 41 publications

(47 reference statements)

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“…TA only benefits the body when its concentration in food is not too high. TA contains active hydroxyl and carboxyl groups that can form complexes with proteins, polysaccharides, alkaloids, and nucleic acids [29,100]. These properties can impede the digestion and absorption of nutrients.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Tannic Acid Consumption on Bone Mineralization

Winiarska-Mieczan,

Muszyński,

Tomaszewska

et al. 2023

Metabolites

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Tannic acid (TA) is an organic compound belonging to the tannin group. Like other tannins, it has an affinity for endogenous proteins, including digestive enzymes, which can result in the reduced digestibility and absorption of nutrients. It can also form complexes with mineral components, reducing their absorption. In some cases, this can be beneficial, such as in the case of toxic metals, but sometimes it may have a detrimental effect on the body when it involves essential mineral components like Ca, P, Mg, Na, K, or Fe. Therefore, the impact of TA on bone health should be considered from both perspectives. This relatively short review summarizes the available information and research findings on TA, with a particular focus on its potential impact on bone health. It is worth noting that future research and clinical studies may provide more detailed and precise information on this topic, allowing for a better understanding of the role of TA in maintaining the integrity of the musculoskeletal system. Despite its brevity, this paper represents a valuable contribution to the analysis of the potential benefits and challenges associated with TA in the context of bone health. We anticipate that future research will continue along this important research line, expanding our knowledge of the influence of this compound on the skeletal system and its potential therapeutic applications.

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Section: Discussionmentioning

confidence: 99%

The Impact of Tannic Acid Consumption on Bone Mineralization

Winiarska-Mieczan,

Muszyński,

Tomaszewska

et al. 2023

Metabolites

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“…Bovine serum albumin (BSA) was extensively investigated as a model globular protein, being one of the most important transporters for endogenous and exogenous molecules in the blood [26,27]. This globular macromolecule presents a predominantly α-helix structure (67%) [28] composed of around 583 amino acid residues.…”

Section: Introductionmentioning

confidence: 99%

Poly(Vinyl Alcohol)/Bovine Serum Albumin Hybrid Hydrogels with Tunable Mechanical Properties

Bercea,

Plugariu,

Dinu

et al. 2023

Polymers

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In this study, a new strategy was adopted for obtaining polymer/protein hybrid hydrogels with shape stability and tunable mechanical or rheological characteristics by using non-toxic procedures. A chemical network was created using a poly(vinyl alcohol)(PVA)/bovine serum albumin (BSA) mixture in aqueous solution in the presence of genipin and reduced glutathione (GSH). Then, a second physical network was formed through PVA after applying freezing/thawing cycles. In addition, the protein macromolecules formed intermolecular disulfide bridges in the presence of GSH. In these conditions, multiple crosslinked networks were obtained, determining the strengthening and stiffening into relatively tough porous hydrogels with tunable viscoelasticity and a self-healing ability. A SEM analysis evidenced the formation of networks with interconnected pores of sizes between 20 μm and 50 μm. The mechanical or rheological investigations showed that the hydrogels’ strength and response in different conditions of deformation were influenced by the composition and crosslinking procedure. Thus, the dynamics of the hybrid hydrogels can be adjusted to mimic the viscoelastic properties of the native tissues. The dynamic water vapor-sorption ability, swelling behavior in an aqueous environment, and bioadhesive properties were also investigated and are discussed in this paper. The hybrid hydrogels with tunable viscoelasticity can be designed on request, and they are promising candidates for tissue engineering, bioinks, and wound dressing applications.

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On surface binding of serum albumin by harmane: An in vitro spectroscopic and theoretical analysis

Tissopi,

Rupreo,

Chaudhuri

et al. 2024

Journal of Molecular Liquids

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Insight into the interaction between tannin acid and bovine serum albumin from a spectroscopic and molecular docking perspective

Abstract: Based on non-covalent bonds, TA could change the secondary structure change of BSA to a certain extent, and improve its thermostability.

Cited by 5 publications

References 41 publications

The Impact of Tannic Acid Consumption on Bone Mineralization

The Impact of Tannic Acid Consumption on Bone Mineralization

Poly(Vinyl Alcohol)/Bovine Serum Albumin Hybrid Hydrogels with Tunable Mechanical Properties

On surface binding of serum albumin by harmane: An in vitro spectroscopic and theoretical analysis

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