Insight into the Effect of Methylglyoxal on the Conformation, Function, and Aggregation Propensity of α‐Synuclein
Laura Mariño,
Ana Belén Uceda,
Francisco Leal
et al.
Abstract:It is well‐known that people suffering from hyperglycemia have a higher propensity to develop Parkinson’s disease (PD). One of the most plausible mechanisms linking these two pathologies is the glycation of neuronal proteins and the pathological consequences of it. α‐Synuclein, a key component in PD, can be glycated at its fifteen lysine. In fact, the end products of this process have been detected on aggregated α‐synuclein isolated from in vivo. However, the consequences of glycation are not entirely clear, w… Show more
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