Insight into the dust explosion hazard of pharmaceutical powders in the presence of flow aids

Bu, Yajie; Addo, Albert; Amyotte, Paul; Yuan, Chunmiao; Chang, Li; Hou, Xiaochen

doi:10.1016/j.jlp.2021.104655

Cited by 11 publications

(2 citation statements)

References 36 publications

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“…The MPRs were widely distributed for Mg, this suggests that the setup may have systematic errors due to differences in the stacking of powder loading or the dispersion of powders at ignition. However, the overall variance of MPR was still in an acceptable range, similar variances were widely observed in dust explosion experiments with other materials [32–34]. Also, MPRs were not proportional to max pressures, it may be due to the inertant (bacteria) and turbulence that occurred during experiments, similar phenomena was reported in previous research [35].…”

Section: Resultssupporting

confidence: 83%

Mg‐based reactive materials with high iodine concentration and biocidal characteristics of aerosolized Mg‐based biocidal materials

Shi,

Hu,

Liu

et al. 2023

Propellants Explo Pyrotec

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This work is aimed to develop a stable Mg‐based thermite with high iodine concentration and preliminarily set a method to test inactivation factor (IF) values of biocidal materials with proximity to the combat situation. First, Mg−I2 composites were mechanochemically prepared and up to 10 wt% of iodine could be retained until the material heated to 265 °C. Then biocidal thermites were mechanochemically prepared using Mg−I2 as a fuel and Ca(IO3)2 as an oxidizer. For Mg−I2−Ca(IO3)2 thermites, apparent aging was observed in the material with a stoichiometric fuel‐to‐oxidizer ratio. In heated filament ignition tests, thermites had ignition temperatures of ~760 °C and ~820 °C at heating rates of 1800 K/s and 13000 K/s, respectively, and were slightly lower than that of pure Mg. Particle combustion test showed that the thermite with more fuel fraction burned faster. A setup based on the constant volume explosion experiment was established to test the inactivation effect of biocidal materials. Results showed that pure Mg had the best inactivation effect, and IF value doesn't have a clear correlation with max pressure achieved by explosions of biocidal materials. For results within the same max pressure range, IF value is proportional to the iodine concentration within the materials. Interestingly, for Mg, IF value was exponentially changed with max pressurization rate, this leads to the unexpected high IF value of Mg. This study shows excessive iodine or oxidizer could deactivate the biocidal material, and the heat release rate may play a crucial role in biocidal performance.

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Section: Resultssupporting

confidence: 83%

Mg‐based reactive materials with high iodine concentration and biocidal characteristics of aerosolized Mg‐based biocidal materials

Shi,

Hu,

Liu

et al. 2023

Propellants Explo Pyrotec

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“…The various studies with respect to the mitigation of the dust explosion studies were carried out by Wei et al, 2020. There is very little information about the various explosion hazards, that are incurred during the handling of the different solvents, reaction mass, and the combustible dust caused during the drying, Jet milling, Multi milling, and shifter, which are used in the powder processing in the pharmaceutical industry (Bu et al, 2022;Eckhoff, 2019;Eckhoff & Li, 2021).…”

Section: Introductionmentioning

confidence: 99%

The New Three-Dimensional Safety Approach for the Implementation of Process Safety Management (PSM) and Improving Safety Aspects for the Pharmaceutical Industry in India – An Overview

Kumar

2024

IJIAS

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Implementation of the fourteen elements of process safety management (PSM) helps to build a good safety culture in the organization. The new three-dimensional approach, which consists of good safety practices, safety precautions, and frequent checking of the process equipment and its devices has been applied to the various elements of the process safety management. The elements of process safety management are six, four, and three are good safety practices, safety precautions, and frequent checking of process equipment and its devices but one of the elements is the combination of all the three-dimensional approach, which is a trade secret, which insists that all the people in the organization should follow all the documented procedures from two to thirteen elements of the process safety management, the controlled copy should only be used inside the company premises. We have taken secondary published data for assessing the deviations of the three-dimensional safety approach for the human failures in the pharmaceutical industry, which has led to various incidents/accidents from October 2017 to September 2021. The deviation, which we have observed for the good safety practices, safety precautions, and frequent checking of process equipment and its devices was ten, nine, and one numbers before implementation of the process safety management. After the implantation of the process safety management, the incidents were reduced to three numbers from January 2022 to August 2023, in which deviation has been found in the two and one for the good safety practices and safety precautions.

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CFD modeling of particle dispersion behavior in the MIKE 3 apparatus

Pan¹,

Spijker²,

Raupenstrauch³

2022

Alexandria Engineering Journal

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Insight into the dust explosion hazard of pharmaceutical powders in the presence of flow aids

Cited by 11 publications

References 36 publications

Mg‐based reactive materials with high iodine concentration and biocidal characteristics of aerosolized Mg‐based biocidal materials

Mg‐based reactive materials with high iodine concentration and biocidal characteristics of aerosolized Mg‐based biocidal materials

The New Three-Dimensional Safety Approach for the Implementation of Process Safety Management (PSM) and Improving Safety Aspects for the Pharmaceutical Industry in India – An Overview

CFD modeling of particle dispersion behavior in the MIKE 3 apparatus

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