Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells

Sládek, Martin; Rybová, Markéta; Jindráková, Zuzana; Zemanová, Zdena; Polidarová, Lenka; Mrnka, Libor; O’Neill, John S.; Pácha, Jiřı́; Sumová, Alena

doi:10.1053/j.gastro.2007.05.053

Cited by 130 publications

(143 citation statements)

References 47 publications

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“…Consistent with previous findings (32), we did not detect expression of the core circadian clock genes period and timeless in the testis niche or stem cells, which suggests that there is no intrinsic clock function in these cells. Interestingly, murine spermatogonial stem cells also lack cell-autonomous circadian clocks (33), which is in contrast to clock-containing hair follicle, hematopoietic, and intestinal stem cells (14,(34)(35)(36). It is possible that central or peripheral circadian clocks located in the brain, other tissues (2), or even other cells of the testes drive rhythms in the GSCs/CPCs, although the absence of mitotic rhythms in constant darkness argues against this possibility (Fig.…”

Section: Discussionmentioning

confidence: 99%

Day–night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis

Tulina

Chen²,

Chen

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Adult stem cells maintain tissue integrity and function by renewing cellular content of the organism through regulated mitotic divisions. Previous studies showed that stem cell activity is affected by local, systemic, and environmental cues. Here, we explore a role of environmental day-night cycles in modulating cell cycle progression in populations of adult stem cells. Using a classic stem cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms in division frequencies of germ-line and somatic stem cells that act cooperatively to produce male gametes. We also examine whether behavioral sleep-wake cycles, which are driven by the environmental day-night cycles, regulate stem cell function. We find that flies lacking the sleep-promoting factor Sleepless, which maintains normal sleep in Drosophila, have increased germ-line stem cell (GSC) division rates, and this effect is mediated, in part, through a GABAergic signaling pathway. We suggest that alterations in sleep can influence the daily dynamics of GSC divisions.

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Section: Discussionmentioning

confidence: 99%

Day–night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis

Tulina

Chen²,

Chen

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Specifically, clock gene expression in the intestinal epithelial cells may control the rhythmic expression of different proteins involved in lipid absorption, such as MTP, apolipoprotein A IV and nocturnin (Hussain and Pan, 2014). Circadian oscillations of clock genes are not restricted only to the intestine, but can also be found in other regions and cell types of the gastrointestinal tract (Hoogerwerf et al, 2007;Pardini et al, 2005;Sladek et al, 2007).…”

Section: Daily Rhythms Of Lipid Metabolismmentioning

confidence: 99%

Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals

Jha

Challet

Kalsbeek

2015

Molecular and Cellular Endocrinology

180

129

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a b s t r a c tMost aspects of energy metabolism display clear variations during day and night. This daily rhythmicity of metabolic functions, including hormone release, is governed by a circadian system that consists of the master clock in the suprachiasmatic nuclei of the hypothalamus (SCN) and many secondary clocks in the brain and peripheral organs. The SCN control peripheral timing via the autonomic and neuroendocrine system, as well as via behavioral outputs. The sleepewake cycle, the feeding/fasting rhythm and most hormonal rhythms, including that of leptin, ghrelin and glucocorticoids, usually show an opposite phase (relative to the lightedark cycle) in diurnal and nocturnal species. By contrast, the SCN clock is most active at the same astronomical times in these two categories of mammals. Moreover, in both species, pineal melatonin is secreted only at night. In this review we describe the current knowledge on the regulation of glucose and lipid metabolism by central and peripheral clock mechanisms. Most experimental knowledge comes from studies in nocturnal laboratory rodents. Nevertheless, we will also mention some relevant findings in diurnal mammals, including humans. It will become clear that as a consequence of the tight connections between the circadian clock system and energy metabolism, circadian clock impairments (e.g., mutations or knock-out of clock genes) and circadian clock misalignments (such as during shift work and chronic jet-lag) have an adverse effect on energy metabolism, that may trigger or enhancing obese and diabetic symptoms.

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“…Thus, this study has uncovered a role for circadian rhythm and Clock protein in macronutrient absorption by the intestine. [4][5][6][7][8][9][10][11][12][13][14] C]cholesterol (58.0 mCi/mmol), [9, H(N)]triolein (22.0 Ci/mmol), [9,10-µm thick), mounted on glass slides, fi xed in ethanol for 15 min at Ϫ 15°C, and washed with PBS at room temperature. The sections were then covered with 5% normal goat serum for 60 min and incubated with anti-Bmal1, Per1, Per2 or Cry1 antibodies at a dilution of 1:50-1:250 for 1 h, washed with PBS for 10 min three times; the sections were incubated with Alexa-conjugated secondary antibodies 1:200 for 1 h and then washed with PBS.…”

Section: Determination Of Mtp Activitymentioning

confidence: 99%

Clock is important for food and circadian regulation of macronutrient absorption in mice

Pan

Hussain

2009

Journal of Lipid Research

181

216

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Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells

Cited by 130 publications

References 47 publications

Day–night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis

Day–night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis

Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals

Clock is important for food and circadian regulation of macronutrient absorption in mice

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