Insight into the chemical bonding and electrostatic potential: A charge density study on a quinazoline derivative

Tojiboev, Akmaljon; Wang, Ruying; Pan, Fangfang; Englert, Ulli; Turgunov, K. K.; Okmanov, R. Ya.

doi:10.1134/s0022476613060036

Cited by 1 publication

(1 citation statement)

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“…They are potential sources of medicines and have shown important pharmacological properties, such as antibacterial, antipyretic, antiviral, and hypoglycemic activities. An alkaloid (-)-lupinine, isolated from Anabasis aphylla L. has also exhibited ant cholinesterase activity [43][44][45][46]. Cytisine (12) is an alkaloid isolated from a plant Thermopsis lanceolata var.…”

Section: Resultsmentioning

confidence: 99%

Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells

Abbas¹,

Al-Harrasi²,

Hussain³

et al. 2017

ijpm

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A b s t r a c tThis study was performed to identify new inhibitors of protein glycation glycation is one of the major causes of late diabetic complications. In this study, terpenoids and alkaloids, isolated from different medicinal plants, along with their derivatives, were evaluated for their antiglycation activity to assess their potential cytotoxicity. Among the tested compounds, gossypol (2,2 1,6,7 and its derivat gazolidone (6), showed a potent antiglycation activity (IC aminoantipyrine (5) showed a significant antiglycation activity with IC µM, in BSA methyl isolated from aphyllin significant inhibition activity with 110.203±4.816µM, respectively. Similarly, compounds gossypol deoxypeganine hydrochloride (8), with IC respectively. The results were compared with the = Cellular cytotoxicity assay showed only gossypol acetic acid (2) and gossypolidene thiocarbamide (3) as somewhat toxic to 3T3 (mouse fibroblast) cells with IC ±0.61 and 5.00 with IC

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Section: Resultsmentioning

confidence: 99%