Insight Into the Binding Mode Knowledge of New Possible Anti-Hypertensive Compounds Designed in Silico Using Neutral Endopeptidase (NEP) As A Target.
Abstract:Arterial hypertension is a health problem that affects millions of people around the world. Particularly in Chile, according to the last health survey in 2019, 28.7% of the population had this condition, and arterial hypertension complications cause one in three deaths per year. In this work, we have used molecular simulation tools to evaluate new compounds designed in silico by our group as possible anti-hypertensive agents, taking Neutral Endopeptidase (NEP) as a target, a key enzyme in the arterial hyperten… Show more
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