Insight into protein synthesis in axon regeneration

Wu, Shuai; Xu, Jiacheng; Dai, Yan; Yu, Bin; Zhu, Jianwei; Mao, Susu

doi:10.1016/j.expneurol.2023.114454

Cited by 3 publications

(2 citation statements)

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“…Researchers are increasingly exploring the role of epitranscriptomic modifications in the development and progression of various neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease, and amyotrophic lateral sclerosis (ALS; Angelova et al, 2018 ; Park et al, 2020 ). It has been suggested that dysregulated regeneration and axon damage are implicated in the pathogenesis of neurodegenerative diseases ( Qian and Zhou, 2020 ; Wu et al, 2023 ). Hongjun Song (University of Pennsylvania, United States) introduced the roles of RNA m 6 A modification during mouse peripheral nervous system (PNS) nerve injury ( Weng et al, 2018 ).…”

Section: Epitranscriptomic Modulation Of Regeneration and Neurodegene...mentioning

confidence: 99%

Exploring the brain epitranscriptome: perspectives from the NSAS summit

Lee,

Koo,

Carré

et al. 2023

Front. Neurosci.

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Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.

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Section: Epitranscriptomic Modulation Of Regeneration and Neurodegene...mentioning

confidence: 99%

Exploring the brain epitranscriptome: perspectives from the NSAS summit

Lee,

Koo,

Carré

et al. 2023

Front. Neurosci.

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“…Similar Wallerian degeneration occurs in neuropathies, such as diabetic neuropathy, where axons and Schwann cells are affected by the different mechanisms of the underlying disease [1]. The biological phenomenon of axonal degeneration and regeneration in a peripheral nerve, which we normally relate to trauma of varying degrees, is fascinating and involves a variety of delicate and well-orchestrated mechanisms in the peripheral nerve [3,4] and in the central nervous system [5]. Axons attempt to regrow after an injury to restore functionality, and the efficiency, the direction, and their relation to other nearby located nerve fibers during the axonal regrowth may be similar irrespective of the why the axons are injured or affected by a disease.…”

Section: Introductionmentioning

confidence: 99%

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

Dahlin

2023

IJMS

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Appropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and other related cells is crucial. Knowledge about key players associated with nerve regeneration intended for axonal outgrowth, migration of Schwann cells with respect to suitable substrates, invasion of macrophages, appropriate conditioning of extracellular matrix, activation of fibroblasts, formation of endothelial cells and blood vessels, and activation of other players in healthy and diabetic conditions is relevant. Appropriate physical and chemical attractions and repulsions are needed for an optimal and directed regeneration and are investigated in various nerve injury and repair/reconstruction models using healthy and diabetic rat models with relevant blood glucose levels. Understanding dynamic processes constantly occurring in neuropathies, like diabetic neuropathy, with concomitant degeneration and regeneration, requires advanced technology and bioinformatics for an integrated view of the behavior of different cell types based on genomics, transcriptomics, proteomics, and imaging at different visualization levels. Single-cell-transcriptional profile analysis of different cells may reveal any heterogeneity among key players in peripheral nerves in health and disease.

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