Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics
Tian‐Hua Wei,
Meng‐Yi Lu,
Si‐Hui Yao
et al.
Abstract:Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity. This review focuses on the structural analysis to elucidate the molecular determinants of JAKs specificity and the discovery and design of selective JAKi. It includes descriptions and comparison of different JAK structures and their binding sites, a comparative analysis of JAKi and their binding modes, detai… Show more
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