Insight Into HCDR3 Restrictions in CLL by Analysis of Incomplete IGHD-IGHJ Rearrangements: Further Evidence that Somatic Selection Shapes the Expressed CLL Immunoglobulin Repertoire.
Abstract:2346
Poster Board II-323
A strong sequence-based evidence supporting a role for antigen in the development of CLL is the existence of subsets of patients with stereotyped heavy complementarity-determining region 3 (HCDR3) sequences. Stereotyped HCDR3s are often defined by the selective association of certain IGHD genes in specific reading frames (RF) with certain IGHJ genes, especially IGHJ6. To gain insight into the mechanisms shaping the IG repertoire and also determine the deve… Show more
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