Insight into epileptic and physiological <i>déjà vu</i>: from a multicentric cohort study

Labate, Angelo; Baggetta, Rossella; Trimboli, Michele; Tripepi, Giovanni; Bisulli, Francesca; D’Aniello, Alfredo; Daniele, Ornella; Bonaventura, Chiara Di; Gennaro, Giancarlo Di; Fattouch, Jinane; Ferlazzo, Edoardo; Ferrari, Alessandra; Gasparini, Sara; Giallonardo, A. T.; Neve, Angela La; Romigi, Andrea; Sofia, Vito; Tinuper, Paolo; Zummo, Leila; Aguglia, Umberto; Gambardella, Antonio

doi:10.1111/ene.13806

Cited by 5 publications

(7 citation statements)

References 21 publications

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“…Seizure-related déjà vu tends to be longer and has other features that are not directly related to the experience of déjà vu: Feelings of depersonalization, fear, or the presence of vivid memories or olfactory hallucinations. This finding is in line with other reports in the literature, such as comparisons between people who experience ictal déjà vu and people with no history of epilepsy who report experiencing déjà vu [18,31]. Despite these differences, the similarities and unique nature of déjà vu have led to speculation that common déjà vu may also be due to focal seizures [32].…”

Section: Introductionsupporting

confidence: 91%

Subjective distinguishability of seizure and non-seizure Déjà Vu: A case report, brief literature review, and research prospects

Cleary¹,

Neisser²,

McMahan³

et al. 2021

Epilepsy & Behavior

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Section: Introductionsupporting

confidence: 91%

Subjective distinguishability of seizure and non-seizure Déjà Vu: A case report, brief literature review, and research prospects

Cleary¹,

Neisser²,

McMahan³

et al. 2021

Epilepsy & Behavior

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“…Interictal déjà vu correlated inversely with age ( 14 , 18 ), and was not associated with sex ( 14 , 18 ). Compared to non-ictal déjà vu in healthy controls, interictal déjà vu was reported lasting equally long, more emotionally negative, and with higher co-occurrence of derealization and depersonalization ( 14 ).…”

Section: Resultsmentioning

confidence: 87%

“…Historically viewed through a mystical lens (5,6), scientific efforts have sought to demystify déjà vu and empirically study it using various methods, including surveys, interviews, neuroimaging techniques, and performance-based neurocognitive assessments. This body of research indicates that déjà vu occurs in both non-clinical (7,8) and clinical populations (9)(10)(11)(12), particularly among epilepsy patients (13,14).…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the affected brain areas, seizures can be categorized as focal, generalized or unknown onset, involving motor or non-motor features, with or without impaired awareness ( 17 ). Epilepsy patients who report déjà vu as part of their seizure semiology are more likely to have focal seizures than other types of seizures ( 14 ). Emerging evidence suggests that these patients may experience two distinct forms of déjà vu: one during seizures and another between seizures ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Non-ictal, interictal and ictal déjà vu: a systematic review and meta-analysis

Hadzic,

Andersson

2024

Front. Neurol.

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BackgroundDéjà vu, French for “already seen,” is a phenomenon most people will experience at least once in their lifetime. Emerging evidence suggests that déjà vu occurs in healthy individuals (as “non-ictal déjà vu”) and in epilepsy patients during seizures (as “ictal déjà vu”) and between seizures (as “interictal déjà vu”). Although the ILAE has recognized déjà vu as a feature of epileptic seizures, it is notably absent from the ICD-11. A lack of evidence-based research may account for this omission. To our knowledge, this study represents the first systematic review and meta-analysis on déjà vu experiences. Through detailed examinations of non-ictal, interictal and ictal déjà vu, we seek to highlight possible clinical implications. Rethinking the status quo of ictal déjà vu could potentially lead to earlier interventions and improve outcomes for epilepsy patients.MethodsThis study was registered in PROSPERO (ID: CRD42023394239) on 5 February 2023. Systematic searches were conducted across four databases: EMBASE, MEDLINE, PsycINFO, and PubMed, from inception to 1 February 2023, limited to English language and human participants. Studies were included/excluded based on predefined criteria. Data was extracted according to the PICO framework and synthesized through a thematic approach. Meta-analyses were performed to estimate prevalence’s of the phenomena. Study quality, heterogeneity, and publication bias were assessed.ResultsDatabase searching identified 1,677 records, of which 46 studies were included. Meta-analyses of prevalence showed that non-ictal déjà vu was experienced by 0.74 (95% CI [0.67, 0.79], p < 0.001) of healthy individuals, whereas interictal déjà vu was experienced by 0.62 (95% CI [0.48, 0.75], p = 0.099) and ictal déjà vu by 0.22 (95% CI [0.15, 0.32], p = 0.001) of epilepsy patients. Examinations of phenomenological (sex, age, frequency, duration, emotional valence, and dissociative symptoms) and neuroscientific (brain structures and functions) data revealed significant variations between non-ictal, interictal and ictal déjà vu on several domains.ConclusionThis systematic review and meta-analysis do not support the notion that non-ictal, interictal and ictal déjà vu are homogenous experiences. Instead, it provides insight into ictal déjà vu as a symptom of epilepsy that should be considered included in future revisions of the ICD-11.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=394239, CRD42023394239.

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“…14 In a study,69% of epileptic cases and 73.1% of healthy individuals reported experiencing déjà vu once in their lifetime. 15 This study does not include any subjects with mental illness because it is understood that people with certain mental diseases like temporal lobe epilepsy may experience more frequent déjà vu than non-epileptic. 16 In our study, gender was not significantly associated with the presence of déjà vu, these results are consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Frequency of DÉJÀ VU Experience and Its Relationship with Stress in Students of The Medical University of Islamabad

Riaz,

Hamza,

Nayab

et al. 2024

JRMC

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Objective: This research aims to evaluate the frequency of déjà vu experience in medical students and its relationship with stress along with different prognostic factors that lead to déjà vu experience. Methods: A descriptive cross-sectional study was conducted at Foundation University Islamabad over 4 months from May 2023 to August 2023. The sample size (239) was calculated using open Epi software with a previous prevalence of 67%. Stratified random sampling was used to select students. Data was collected through a questionnaire containing demographic variables from a validated déjà vu inventory and stress tool. Analysis was done on a validated déjà vu inventory and perceived stress scale 10. SPSS 26 was used to assess the relationship between stress and the frequency of déjà vu using the chi-square test, with statistical significance at p<0.05. Results: 89.2% of the participants reported that they had experienced this sensation at least once in their life. The most popular ways this feeling happened were in a certain place or a certain situation. The association between stress and Déjà vu experiences was found to be significant(p-value 0.012) Conclusion: 89.2% of the participants reported that they had experienced Déjà vu sensation at least once. There was a significant association between stress among medical university students and Déjà vu experience. Keywords: Déjà vu, Stress, Familiarity, Sensation, Epilepsy, Dopamine.

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Insight into epileptic and physiological déjà vu: from a multicentric cohort study

Cited by 5 publications

References 21 publications

Subjective distinguishability of seizure and non-seizure Déjà Vu: A case report, brief literature review, and research prospects

Subjective distinguishability of seizure and non-seizure Déjà Vu: A case report, brief literature review, and research prospects

Non-ictal, interictal and ictal déjà vu: a systematic review and meta-analysis

Frequency of DÉJÀ VU Experience and Its Relationship with Stress in Students of The Medical University of Islamabad

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