Insight Into Chromatin-Enriched RNA: A Key Chromatin Regulator in Tumors

Zhang, Jixing; Ding, Tianyi; Zhang, He

doi:10.3389/fcell.2021.649605

Cited by 8 publications

(7 citation statements)

References 118 publications

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“…The lack of chromatin regulators ASXL1 activates RAS signaling pathways, accelerating the progress of myeloid malignancies ( Zhang, Jiang et al, 2019 ). CheRNA is a rich blend of RNA regulators in the function of tumors associated with CSC proliferation and dry maintenance ( Zhang, Ding et al, 2021 ). PRC2 mediates the trimethylation of lysine 27 to histone H3, a key factor regulating epigenetic plasticity in gliomas ( Natsume, Ito et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Characterization of chromatin regulators in hepatocellular carcinoma to guide clinical therapy

Jia

Zhang

2022

Front. Genet.

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Background: Hepatocellular carcinoma (HCC) is notorious for its high mortality and incidence. Accumulating evidence confirms that chromatin regulators (CRs) have a significant impact on cancer. Therefore, exploring the mode of action and prognostic value of CRs is imminent for the treatment of hepatocellular carcinoma.Method: Transcriptome and clinical data for this study have been downloaded from TCGA (https://portal.gdc.cancer.gov/) and ICGC (https://dcc.icgc.org/). Univariate analysis was used to screen CRs with prognostic value, and our prognostic risk score signature was developed using least absolute shrinkage along with selection operator (lasso) Cox regression analysis. The CRs-based prognostic model was constructed in the TCGA dataset, and low-risk HCC patients had a better prognosis, which was finally validated in the ICGC dataset. We used the receiver operating characteristic curve to identify the accuracy of the prediction model and establish a line chart to prove the clinical effectiveness of the model. We also discussed the differences in drug sensitivity via CellMiner database, tumor immune microenvironment via ssGSEA algorithm, and clinical characteristics among different risk groups.Results: A prognostic model consisting of seven CRs was constructed and verified in HCC patients. Furthermore, we found that this risk score prognostic signature could independently predict the prognosis of HCC patients. Functional enrichment analysis revealed that CRs are mainly associated with cancer-related signaling pathways and metabolic pathways. In addition, immune cell abundance correlates with risk score levelsConclusion: In brief, we systematically explored the mode of action of CRs in HCC patients and established a reliable prognostic prediction model.

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Section: Discussionmentioning

confidence: 99%

Characterization of chromatin regulators in hepatocellular carcinoma to guide clinical therapy

Jia

Zhang

2022

Front. Genet.

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“…In recent years, lncRNAs have been shown to play an important role in the occurrence and development of many cancers ( 20 , 21 ), including CRC ( 22 , 23 ). In this article, we performed high-throughput sequencing on 3 cases of fresh CRC and corresponding adjacent tissues.…”

Section: Discussionmentioning

confidence: 99%

LncRNA-ENST00000543604 exerts a tumor-promoting effect via miRNA 564/AEG-1 or ZNF326/EMT and predicts the prognosis of and chemotherapeutic effect in colorectal cancer

et al. 2022

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ObjectivesColorectal cancer(CRC) is a common malignant tumor. Recent studies have found that lncRNAs play an important role in the occurrence and development of colorectal cancer.MethodsBased on high-throughput sequencing results of fresh CRC tissues and adjacent tissues, we identified lncRNA-ENST00000543604 (lncRNA 604) as the research object by qRT-PCR in CRC tissues and cells. We explored the mechanism of lncRNA 604 action by using luciferin reporter, qRT-PCR and Western blot assays. Kaplan-Meier survival analysis and a Cox regression model were used to analyze the correlation of lncRNA 604 and its regulatory molecules with the prognosis of and chemotherapy efficacy in CRC patients.ResultsIn this study, we found that the expression levels of lncRNA 604 were increased in CRC. LncRNA 604 could promote CRC cell proliferation and metastasis through the miRNA 564/AEG-1 or ZNF326/EMT signaling axis in vivo and in vitro. LncRNA 604 could predict the prognosis of CRC and was an independent negative factor. LncRNA 604 exerted a synergistic effect with miRNA 564 or ZNF326 on the prognosis of CRC. LncRNA 604 could improve chemoresistance by increasing the expression of AEG-1, NF-κB, and ERCC1.ConclusionsOur study demonstrated that lncRNA 604 could promote the progression of CRC via the lncRNA 604/miRNA 564/AEG-1/EMT or lncRNA 604/ZNF326/EMT signaling axis. LncRNA 604 could improve chemoresistance by increasing drug resistance protein expression.

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“…Long non‐coding RNAs (lncRNAs), a class of transcripts over 200 nt in length, were originally thought to be transcriptional noise owing to the lack of protein‐coding ability 5,6 . In recent years, lncRNAs have been conspicuous in the study of the molecular mechanism of cancer.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA 02027 inhibits proliferation, migration and invasion of hepatocellular carcinoma via miR‐625‐3p/PDLIM5 pathway

Wang

Wan

et al. 2023

The Journal of Gene Medicine

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Background: Long non-coding RNAs have been established to promote or inhibit the oncogenic and tumorigenic potential of various cancers, acting as competing endogenous RNAs (ceRNAs) for specific microRNAs. The primary objective of the study was to investigate the underlying mechanism by which the LINC02027/miR-625-3p/ PDLIM5 axis affects proliferation, migration and invasion in hepatocellular carcinoma (HCC). Methods:The differentially expressed gene was selected based on gene sequencing and bioinformation database analysis of HCC and adjacent non-tumor tissues. The expression of LINC02027 in HCC tissues and cells and its regulatory effect on the development of HCC were detected by colony formation, cell counting kit-8 assays, wound healing assays, Transwell assays and subcutaneous tumorigenesis assays in nude mice. According to the results of database prediction, quantitative real-time polymerase chain reaction and dual-luciferase reporter assay, the downstream microRNA and target gene were searched. Finally, HCC cells were transfected with lentivirus and used for cell function assays in vitro and in vivo.Results: Downregulation of LINC02027 was detected in HCC tissues and cell lines and was associated with poor prognosis. The overexpression of LINC02027 suppressed the proliferation, migration and invasion of HCC cells. Mechanistically, LINC02027 inhibited epithelial-to-mesenchymal transition. As a ceRNA, LINC02027 inhibited the malignant ability of HCC by competitively binding to miR-625-3p to regulate the expression of PDLIM5.

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Insight Into Chromatin-Enriched RNA: A Key Chromatin Regulator in Tumors

Cited by 8 publications

References 118 publications

Characterization of chromatin regulators in hepatocellular carcinoma to guide clinical therapy

Characterization of chromatin regulators in hepatocellular carcinoma to guide clinical therapy

LncRNA-ENST00000543604 exerts a tumor-promoting effect via miRNA 564/AEG-1 or ZNF326/EMT and predicts the prognosis of and chemotherapeutic effect in colorectal cancer

Long noncoding RNA 02027 inhibits proliferation, migration and invasion of hepatocellular carcinoma via miR‐625‐3p/PDLIM5 pathway

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