Insight into C4 Selectivity in the Light‐Driven C−H Fluoroalkylation of Pyridines and Quinolines
Leejae Kim,
Wooseok Lee,
Sungwoo Hong
Abstract:Given the prevalence of pyridine motifs in FDA‐approved drugs, selective fluoroalkylation of pyridines and quinolines is essential for preparing diverse bioisosteres. However, conventional Minisci reactions often face challenges in achieving precise regioselectivity due to competing reaction sites of pyridine and the limited availability of fluoroalkyl radical sources. Herein, we present a light‐driven, C4‐selective fluoroalkylation of azines utilizing N‐aminopyridinium salts and readily available sulfinates. … Show more
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