2015
DOI: 10.1016/j.anaerobe.2015.03.008
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Insight into alteration of gut microbiota in Clostridium difficile infection and asymptomatic C. difficile colonization

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Cited by 115 publications
(152 citation statements)
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“…Human studies have also implicated particular microbial taxa in modulating susceptibility to CDI. In general, high levels of members of the phylum Bacteroidetes, consisting of strictly Gram-negative anaerobes, are thought to be protective against CDI, whereas increased numbers of Proteobacteria are thought to increase susceptibility (58,59,99,114,115). These correlations are also consistent with observations that FMT recipients have increased levels of Bacteroidetes and decreased levels of Proteobacteria following recovery from CDI (92,93,95,116).…”
Section: Microbial Taxa Associated With Colonization Resistance Againsupporting
confidence: 79%
See 1 more Smart Citation
“…Human studies have also implicated particular microbial taxa in modulating susceptibility to CDI. In general, high levels of members of the phylum Bacteroidetes, consisting of strictly Gram-negative anaerobes, are thought to be protective against CDI, whereas increased numbers of Proteobacteria are thought to increase susceptibility (58,59,99,114,115). These correlations are also consistent with observations that FMT recipients have increased levels of Bacteroidetes and decreased levels of Proteobacteria following recovery from CDI (92,93,95,116).…”
Section: Microbial Taxa Associated With Colonization Resistance Againsupporting
confidence: 79%
“…Antibiotic treatment depletes members of the two dominant bacterial phyla in the gut, the Bacteroidetes and Firmicutes (56,57). Antibiotics also lead to increases in the numbers of Proteobacteria, which are associated with susceptibility to CDI in humans (56)(57)(58)(59). Studies in both humans and animals have indicated that changes in the microbiota brought on by antibiotic treatment can be long lasting, although this depends on the antibiotic used (56,57,60,61).…”
Section: Risk Factors For Developing CDImentioning
confidence: 99%
“…found that samples from asymptomatic carriers exhibited decreased diversity, similar to samples obtained from CDI patients, but were structurally more similar to healthy control samples (66). The asymptomatic carrier specimens contained fewer Proteobacteria than CDI samples and a greater abundance of Bifidobacteria, which were completely lacking in the CDI specimens (66). These data suggest that the presence or absence of certain microbial taxa is more important than microbial diversity when considering CDI susceptibility.…”
Section: Difficile and The Gut Microbiomementioning
confidence: 96%
“…Two small studies have suggested that differences in the host microbiota could be a potential mechanism that distinguishes between asymptomatic carriage and disease (61, 62). By comparing microbial community composition between four patients with CDI, four asymptomatically colonized patients and non-colonized controls, Vincent et al (62) found that organisms classified as members of the Clostridiales incertae sedis XI family, Eubacterium species, or Clostrdium species other than C. difficile were enriched in asymptomatically colonized patients compared to patients with symptomatic CDI.…”
Section: Clostridium Difficile Carriage and Diseasementioning
confidence: 99%
“…By comparing microbial community composition between four patients with CDI, four asymptomatically colonized patients and non-colonized controls, Vincent et al (62) found that organisms classified as members of the Clostridiales incertae sedis XI family, Eubacterium species, or Clostrdium species other than C. difficile were enriched in asymptomatically colonized patients compared to patients with symptomatic CDI. By comparing eight symptomatically infected patients, eight asymptomatically colonized C. difficile patients, and healthy controls, Zhang et al (61) observed trends towards increased levels of Bacteroides, Lachnospiraceae incertae sedis , and Clostridium XIVa species and statistically significant decreases in the levels of Escherichia/Shigella species in asymptomatically colonized patients compared to healthy controls. Both asymptomatically colonized patients and patients with CDI also had significantly decreased microbial diversity compared to healthy controls.…”
Section: Clostridium Difficile Carriage and Diseasementioning
confidence: 99%