Insight in Schizophrenia: Relationship to Positive, Negative and Neurocognitive Dimensions

Joseph, Boban; Narayanaswamy, Janardhanan C.; Venkatasubramanian, Ganesan

doi:10.4103/0253-7176.150797

Cited by 35 publications

(21 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lack of insight is considered a core manifestation of schizophrenia (DSM-IV-TR). Presence of insight may have important implications for outcomes and recovery in schizophrenia, as individuals with poor insight may not be adherent to medications or psychotherapy (Kay et al, 1987; Karow et al, 2008; Joseph et al, 2015). Mohanty and Kumar (2012) reported in their study that CI is an important mediator of response to cognitive behaviour therapy for psychosis, acting as a predictor of improvement in positive, negative as well as general psychopathology symptoms (Granholm et al, 2005; Perivoliotis et al, 2010; Premkumar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Cognitive insight and objective quality of life in people with schizophrenia and auditory hallucinations

Rathee

Luhrmann

Bhatia

et al. 2018

Psychiatry Research

View full text Add to dashboard Cite

Poor cognitive insight in schizophrenia has been linked to delusions, hallucinations, and negative symptoms as well as to depressive/anxiety symptoms. Its impact on quality of life has been less studied, especially in schizophrenia subjects with ongoing auditory hallucinations. The Beck Cognitive Insight Scale (BCIS) and the Quality of Life Scale (QLS) were administered to subjects who met DSM IV criteria for schizophrenia after due translation and validation. All subjects reported ongoing auditory hallucinations at recruitment. Mean composite cognitive insight scores from participants (N = 60) (2.97 ± 2.649) were in the lower range as compared to published literature. Cognitive insight scores as well as self-reflectiveness subscale scores, but not self-certainty scores, correlated significantly with the QLS scores p < 0.001. Results suggest that better cognitive insight, especially self-reflectiveness, may be linked to better quality of life. Self-reflectiveness could be a useful construct to address in psychotherapy to improve rehabilitation.

show abstract

Section: Introductionmentioning

confidence: 99%

Cognitive insight and objective quality of life in people with schizophrenia and auditory hallucinations

Rathee

Luhrmann

Bhatia

et al. 2018

Psychiatry Research

View full text Add to dashboard Cite

show abstract

“…Poor insight is seen as the most common and absolute barrier to SDM among patients with schizophrenia ( 32 , 47 ) and has been linked to a poorer perceived therapeutic alliance ( 73 ). This can be explained by the description of insight as the ability of people with schizophrenia to recognize that they have an illness and their ability to understand how their experiences relate to the illness ( 74 ).…”

Section: Discussionmentioning

confidence: 99%

Shared Decision-Making and Role Preference Among Patients With Schizophrenia in Malaysia: A Cross-Sectional Study

Ismail

Midin

2021

Front. Psychiatry

View full text Add to dashboard Cite

Introduction: Shared decision-making (SDM) is recognized as a promising strategy for improving collaboration between clinicians and their patients in achieving recovery. In Malaysia, SDM among people with schizophrenia is still lacking both in practice and in research. This study aimed to determine the level of SDM and role preference and their associated factors among patients with schizophrenia in Malaysia.Methods: A cross-sectional study was conducted on 86 outpatient attendees with schizophrenia at a teaching hospital in Kuala Lumpur, Malaysia. The nine-item Shared Decision Making Questionnaire and Control Preference Scale were used to assess perceived SDM experience and role preference, respectively. Linear and logistic regression models were used to analyze the factors associated with SDM and role preference, respectively. Factors with a p <0.25 from the simple regression analyses were controlled as the covariates in the multiple regression analyses.Results: The study respondents were predominantly female, single, and unemployed, with a mean age of 44 years. Only 35% of the participants reported having high SDM experiences, even though the majority (56%) preferred autonomous role preference. Among the participants who preferred autonomous roles, only 40% experienced high SDM. High SDM was found to be significantly associated with being younger (B = −0.33, 95% CI = −0.67 to −0.003) and being non-clozapine users (B = 19.90, 95% CI = 9.39–30.41), while autonomous role preference was significantly associated with a lower level of insight [adjusted odds ratio (AOR) = 0.84, 95% CI = 0.72–0.99] and being on oral antipsychotic drugs only (AOR = 2.94, 95% CI = 1.10–7.82).Conclusion: The practice of SDM is still lacking in the treatment of patients with schizophrenia in Malaysia, even though many of them preferred to be involved in the decision-making pertaining to their treatment. This study indicates the need for clinicians to improve their patients' involvement in the treatment process. More research is needed on how SDM can be implemented in patients with schizophrenia, especially in Asian population settings.

show abstract

“…Schizophrenia is a chronic debilitating neurodevelopmental disorder that affects approximately 1% of the population worldwide; the first symptoms emerge during adolescence and early adulthood. It is characterized by a combination of positive (auditory and visual hallucination), negative (social withdrawal, anxiety), and cognitive symptoms (impaired memory, decision-making difficulties; Joseph et al, 2015 ). Following our seminal 2002 article (Andrieux et al, 2002 ), numerous studies were performed and their findings reinforced the validity of the MAP6 KO model for the study of schizophrenia.…”

Section: Map6 Protein Is a Multi-functional Proteinmentioning

confidence: 99%

Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories

Cuveillier

Boulan

Ravanello

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and activity, it was recently recognized to play the role of a signaling platform. Following this recognition, research into Microtubule Associated Proteins (MAPs) diversified. Indeed, historically, structural MAPs—including MAP1B, MAP2, Tau, and MAP6 (also known as STOP);—were identified and described as MT-binding and -stabilizing proteins. Extensive data obtained over the last 20 years indicated that these structural MAPs could also contribute to a variety of other molecular roles. Among multi-role MAPs, MAP6 provides a striking example illustrating the diverse molecular and cellular properties of MAPs and showing how their functional versatility contributes to the central nervous system. In this review, in addition to MAP6’s effect on microtubules, we describe its impact on the actin cytoskeleton, on neuroreceptor homeostasis, and its involvement in signaling pathways governing neuron development and maturation. We also discuss its roles in synaptic plasticity, brain connectivity, and cognitive abilities, as well as the potential relationships between the integrated brain functions of MAP6 and its molecular activities. In parallel, the Collapsin Response Mediator Proteins (CRMPs) are presented as examples of how other proteins, not initially identified as MAPs, fall into the broader MAP family. These proteins bind MTs as well as exhibiting molecular and cellular properties very similar to MAP6. Finally, we briefly summarize the multiple similarities between other classical structural MAPs and MAP6 or CRMPs.In summary, this review revisits the molecular properties and the cellular and neuronal roles of the classical MAPs, broadening our definition of what constitutes a MAP.

show abstract

Insight in Schizophrenia: Relationship to Positive, Negative and Neurocognitive Dimensions

Cited by 35 publications

References 77 publications

Cognitive insight and objective quality of life in people with schizophrenia and auditory hallucinations

Cognitive insight and objective quality of life in people with schizophrenia and auditory hallucinations

Shared Decision-Making and Role Preference Among Patients With Schizophrenia in Malaysia: A Cross-Sectional Study

Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories

Contact Info

Product

Resources

About