Inside the minds of mice and men

Baker, Monya

doi:10.1038/475123a

Cited by 55 publications

(45 citation statements)

References 11 publications

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“…Further study is required to extend our analytical toolbox to include a wider range of more subtle socio-behavioural parameters, such as sexual and aggressive behaviours, possibly by incorporating modules that allow for further analysis of our tracking data together with newly developed vision-based behavioural phenotyping programs 11,12 . In its current state, our system may allow rapid and systematic analysis of sets of locomotion and socio-behavioural mouse phenotypes across multiple wild-type strains and in the numerous available genetically modified models for neuropsychiatric disorders (for example, anxiety, autism and schizophrenia) 1,5,39 .…”

Section: Discussionmentioning

confidence: 99%

“…It requires the tracking of multiple identified individuals with a high spatiotemporal precision that can allow for accurate identification of a complex series of behavioural patterns. Manual quantification of such behavioural traits requires a vast time investment in terms of both training and analysis, while remaining susceptible to errors and subjectivity, and potentially overlooking the most meaningful phenotypes [5][6][7] .…”

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confidence: 99%

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Automated long-term tracking and social behavioural phenotyping of animal colonies within a semi-natural environment

et al. 2013

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Social behaviour has a key role in animal survival across species, ranging from insects to primates and humans. However, the biological mechanisms driving natural interactions between multiple animals, over long-term periods, are poorly studied and remain elusive. Rigorous and objective quantification of behavioural parameters within a group poses a major challenge as it requires simultaneous monitoring of the positions of several individuals and comprehensive consideration of many complex factors. Automatic tracking and phenotyping of interacting animals could thus overcome the limitations of manual tracking methods. Here we report a broadly applicable system that automatically tracks the locations of multiple, uniquely identified animals, such as mice, within a semi-natural setting. The system combines video and radio frequency identified tracking data to obtain detailed behavioural profiles of both individuals and groups. We demonstrate the usefulness of these data in characterizing individual phenotypes, interactions between pairs and the collective social organization of groups.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Automated long-term tracking and social behavioural phenotyping of animal colonies within a semi-natural environment

et al. 2013

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“…According to this strict interpretation, none of the ELS models display reduced SA (they all demonstrate preference for the novel rat chamber over the novel object chamber) (Bernard et al, 2013; Lugo et al, 2014b). Since rats are more socially complex (Baker, 2011; Chiappa et al, 1979; Dolgin, 2010; Iannaccone and Jacob, 2009; Jacob, 1999), other groups have used a more liberal interpretation of SA. For example following KA-P7, ELS rats spent significantly less time in the novel rat chamber compared to controls.…”

Section: Behavioral Phenotypes Following Elsmentioning

confidence: 99%

“…Communication has been extensively studied in mouse genetic models of autism (Crawley, 2012; Wohr, 2014; Wohr and Scattoni, 2013; Wohr and Schwarting, 2013) and this work has now begun in rat genetic models (Engineer et al., 2014a, b). Translation of these assays from the mouse to the rat is a priority as rats are the preferred rodent species to measure higher order cognitive tasks (Baker, 2011; Chiappa et al, 1979; Dolgin, 2010; Ianaccone and Jacob, 2009; Jacob, 1999). …”

Section: Behavioral Phenotypes Following Elsmentioning

confidence: 99%

Early life seizures: Evidence for chronic deficits linked to autism and intellectual disability across species and models

Bernard

Benke

2015

Experimental Neurology

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Recent work in Exp Neurol by Lugo et al. (2014b) demonstrated chronic alterations in sociability, learning and memory following multiple early life seizures (ELS) in a mouse model. This work adds to the growing body of evidence supporting the detrimental nature of ELS on the developing brain to contribute to aspects of an autistic phenotype with intellectual disability. Review of the face validity of behavioral testing and the construct validity of the models used informs the predictive ability and thus the utility of these models to translate underlying molecular and cellular mechanisms into future human studies.

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“…Researchers interested in collecting behavioural data to investigate the decision processes and communication strategies in humans and animals have taken advantage of new tools and approaches (e.g. Knoppien, van der Pers & van Delden 2000;Baker 2011;Shteynberg et al 2014). The use of photo and video cameras and audio recorders that can store a large amount of data is now widespread in fields like psychology, primatology, entomology, anthropology, ornithology, medicine, neuroscience and cognitive science (e.g.…”

Section: Introductionmentioning

confidence: 99%

BORIS: a free, versatile open‐source event‐logging software for video/audio coding and live observations

2016

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Summary1. Quantitative aspects of the study of animal and human behaviour are increasingly relevant to test hypotheses and find empirical support for them. At the same time, photo and video cameras can store a large number of video recordings and are often used to monitor the subjects remotely. Researchers frequently face the need to code considerable quantities of video recordings with relatively flexible software, often constrained by speciesspecific options or exact settings. 2. BORIS is a free, open-source and multiplatform standalone program that allows a user-specific coding environment to be set for a computer-based review of previously recorded videos or live observations. Being open to user-specific settings, the program allows a project-based ethogram to be defined that can then be shared with collaborators, or can be imported or modified. 3. Projects created in BORIS can include a list of observations, and each observation may include one or two videos (e.g. simultaneous screening of visual stimuli and the subject being tested; recordings from different sides of an aquarium). Once the user has set an ethogram, including state or point events or both, coding can be performed using previously assigned keys on the computer keyboard. BORIS allows definition of an unlimited number of events (states/point events) and subjects. 4. Once the coding process is completed, the program can extract a time-budget or single or grouped observations automatically and present an at-a-glance summary of the main behavioural features. The observation data and time-budget analysis can be exported in many common formats (TSV, CSV, ODF, XLS, SQL and JSON). The observed events can be plotted and exported in various graphic formats (SVG, PNG, JPG, TIFF, EPS and PDF).

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Inside the minds of mice and men

Abstract: Monitoring technologies and genetic engineering are producing a growing array of animal models for psychiatric disorders, but researchers are still learning how best to use them.

Cited by 55 publications

References 11 publications

Automated long-term tracking and social behavioural phenotyping of animal colonies within a semi-natural environment

Automated long-term tracking and social behavioural phenotyping of animal colonies within a semi-natural environment

Early life seizures: Evidence for chronic deficits linked to autism and intellectual disability across species and models

BORIS: a free, versatile open‐source event‐logging software for video/audio coding and live observations

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