Inside Front Cover: Quantitative phosphoproteomic analysis reveals system‐wide signaling pathways regulated by site‐specific phosphorylation of Keratin‐8 in skin squamous cell carcinoma derived cell‐line

Abstract

DOI: https://doi.org/10.1002/pmic.201600254 Phosphorylation is a major regulator of Keratin 8 canonical functions but its role in skin squamous cell carcinoma and the underlying mechanism is still uncertain. Our mutational studies followed by tandem mass tag based global quantitative phosphoproteome profiling provides many new start points to delineate mechanisms governing K8 phosphorylation mediated oncogenic potential of A431 cells. The biochemical and phenotypic validations further strengthen these findings. Altogether this study suggests a much broader regulatory role of K8 phosphorylation in cancer. For more details, see the research article by Richa Tiwari et al., article number 1600254.