Inside Cover: Spirofused and Annulated 1,2,4‐Trioxepane‐, 1,2,4‐Trioxocane‐, and 1,2,4‐Trioxonane‐Cyclohexadienones: Cyclic Peroxides with Unusual Ring Conformation Dynamics (Angew. Chem. Int. Ed. 42/2018)

Abstract

The dichotomy of the dangerous and healthy properties of medium‐sized cyclic peroxides, which are used as medicinal agents and energetic materials, is explained by A. G. Griesbeck et al. in their Communication on page 13770 ff. They attribute the decrease in the gain of stabilization of spirofused and ring‐annulated peroxides (determined from the Gibbs energy difference between starting materials and products) with increasing ring size to the opposing effects of stabilizing natural bond orbital (NBO) interactions and destabilizing ring strain.