Inside Cover: Selective Inhibition of Aggregation and Toxicity of a Tau‐Derived Peptide using Its Glycosylated Analogues (Chem. Eur. J. 17/2016)

Abstract

Amyloid formation is attenuated by a single glycan unit. Using β‐O‐linked glycosylated variants of the Tau‐derived hexapeptide motif, VQIVYK, which served as a simplified amyloid model scaffold, it is demonstrated that amyloid formation and toxicity can be strongly attenuated by a glycan unit, depending on the nature of the glycan itself. Moreover, the glycosylated peptides inhibit aggregation of the corresponding non‐modified amyloid scaffold. More information can be found in the Full Paper by D. Segal, S. Rahimipour, E. Gazit et al. on page 5945 ff.