Inside Cover: Enzymatic or In Vivo Installation of Propargyl Groups in Combination with Click Chemistry for the Enrichment and Detection of Methyltransferase Target Sites in RNA (Angew. Chem. Int. Ed. 21/2018)

Abstract

A precise mapping approach to detect RNA methyltransferase target sites is described by A. Rentmeister et al. in their Communication on page 6342 ff. A bioorthogonal propargyl group is enzymatically transferred to RNA, and the methyltransferase target sites can then be detected through bioconjugation, enrichment, and next‐generation sequencing. The picture shows the mapping of an RNA forest through the introduction of a propargyl group to distinguish between modified and non‐modified adenosines.