Inside Cover: Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (ChemMedChem 5/2013)

Abstract

The inside cover picture shows a DNA-targeting artemisinin-netropsin drug conjugate docked into d(CGCGAATTCGCG) duplex DNA (PDB code: 1D86). The conjugate combines a trioxane warhead and a minor groove binder joined through a phenyl linker. For more details, see the Communication by Paul M. O'Neill et al. on p. 709 ff.