Abstract:The inside back cover picture shows a rational peptide‐design approach for the development of inhibitors of the serine proteases kallikrein‐related peptidases 7 (KLK7) and 5 (KLK5). Hybrid peptides combining the scaffold of the bicyclic peptide sunflower trypsin inhibitor‐1 (SFTI‐1) with amino acid sequences derived from the reactive center loops of different serpins were generated by solid‐phase peptide synthesis. Some of these molecules displayed nanomolar protease inhibition, and it was demonstrated that se… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.