Inside Back Cover: Highly Efficient Self‐Assembly of Metallacages and Their Supramolecular Catalysis Behaviors in Microdroplets (Angew. Chem. Int. Ed. 27/2023)

Abstract

A highly efficient strategy for the supramolecular self‐assembly of well‐defined metallacages in microdroplets through continuous‐flow microfluidic devices is described by Lin Xu and co‐workers in their Research Article (e202301900). The strategy adds a highly efficient approach to the toolbox of metallacage self‐assembly.

Recent advances in combatting bacterial infections via well-designed metallacycles/metallacages

“…biotics powerfully, but the biosafety of these drugs remains a great challenge in clinical application. Thus, the biosafety of SCCs is a key issue to be solved nowadays, and perhaps we can try to use some essential metal elements, such as Zn, Mn, and Fe, 88,89 as the receptors of ligands in anticipation of the application of SCCs in clinical research.…”

Water-Soluble, Self-Assembled Molecular Cage and Two-Dimensional Framework through Flexibility Adjustment of the Precursors

“…18−20 The self-assembly process can give rise to different supramolecular structures, including supramolecular macrocycles, 21−24 cages, 23−31 frameworks, 32−37 etc. The determinants of the formation of various self-assembled structures are influenced by various factors, including molecular design, 38,39 the driving forces (diversified noncovalent interactions), 40−42 solvent effects, 43,44 external conditions (concentration, temperature, pH, et al), 45,46 and so on. 47,48 Among all of the self-assembly processes, the study of aqueous self-assembly holds significant importance due to its relevance to biology and potential biomedical applications.…”

“…Supramolecular self-assembly refers to the spontaneous formation of highly ordered complex structures through noncovalent interactions such as hydrogen bonding, − π–π stacking, − host–guest interactions, − hydrophobic/hydrophilic interactions, − and so on. − The self-assembly process can give rise to different supramolecular structures, including supramolecular macrocycles, − cages, − frameworks, − etc. The determinants of the formation of various self-assembled structures are influenced by various factors, including molecular design, , the driving forces (diversified noncovalent interactions), − solvent effects, , external conditions (concentration, temperature, pH, et al), , and so on. , Among all of the self-assembly processes, the study of aqueous self-assembly holds significant importance due to its relevance to biology and potential biomedical applications. Many biological processes, such as protein folding, enzyme activity, and cell signaling, occur in aqueous environments. − By studying aqueous self-assembly, we can gain insights into the fundamental principles underlying biological self-assembly and mimic biological processes for biomedical applications .…”