Inside Back Cover: Dienophile‐Modified Mannosamine Derivatives for Metabolic Labeling of Sialic Acids: A Comparative Study (ChemBioChem 13/2017)

Abstract

The inside back cover picture shows the principle of metabolic glycoengineering that has it roots in Werner Reutter's research of 1992. Modified carbohydrate derivatives cross the cell membrane (symbolized by the Old Rhine Bridge in Konstanz) and enter the glycan biosynthesis pathway, which eventually leads to the presentation of the modified glycans as part of cell‐surface proteins and lipids. There, they can undergo a bioorthogonal ligation reaction, for example a tetrazine ligation, allowing them to be visualized by fluorescence microscopy. More information can be found in the full paper by V. Wittmann et al. on page 1242 in Issue 13, 2017 (DOI: 10.1002/cbic.201700002).