Insertion variant in intron 9, but not microsatellite in intron 2, of the insulin receptor gene is associated with essential hypertension

Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals.

“…Allele frequencies for polymorphisms at 12 other loci studied previously (20,21,(23)(24)(25)(26)(27)(28)(29) showed no change with age in either the NT or HT group (data not shown). In addition, genotype frequencies for these variants obeyed Hardy-Weinberg equilibrium in both the NT and HT groups, with the exception of one which has been shown previously to be associated with HT (21,26,29 (Fig.…”

“…Virtually all were volunteers. Further details of ascertainment and other information have been described previously (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Table I shows demographic parameters for each group.…”

Genome-wide scan of resistin mRNA expression in omental adipose tissue of baboons

“…Mutations in INSR have been observed in insulin resistance syndromes, and a polymorphism in intron 9 of the INSR gene was associated with hypertension. 37 As described above, resistin has been associated with insulin sensitivity in humans 9 and mice, 2 but its relationship with the insulin receptor gene is unexplored.…”

A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese

“…23,24 The multiple logistic regression analysis revealed that the C1773T polymorphism is an independent predisposing factor for hypertension (Table 5). Several candidate genes showing the positive association with hypertension (insulin receptor, 25 glycogen synthase, 26 and prostaglandin I 2 receptor 27 )…”