2018
DOI: 10.1016/s2095-3119(18)61916-1
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Insertion site of FLAG on foot-and-mouth disease virus VP1 G-H loop affects immunogenicity of FLAG

Abstract: The G-H loop of the foot-and-mouth disease virus (FMDV) virion contains certain dominant immunogenic epitopes, as well as an arginine-glycine-aspartic acid (RGD) motif that is recognized by cell surface integrin receptors. Previous experiments indicate that it is critical to maintain virus structural integrity when inserting an exogenous epitope into the surface of an FMDV structural protein. However, it remains to be determined how factors such as different insertion positions affect interactions among the vi… Show more

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Cited by 3 publications
(1 citation statement)
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“…Many vaccines have been used, together with companion diagnostic assays, as marker vaccines, such as chimeric FMDV vaccines [47], the partial VP1 G-H loop vaccine [48], FMD-negative marker vaccines [49], a vaccine with an exogenous FLAG epitope in RGD-4 [136], the Cav-P1/3C R° FMDV vaccine [36], the 3AB-truncated virus and its…”
Section: Marker Vaccine Development and Diva Assaysmentioning
confidence: 99%
“…Many vaccines have been used, together with companion diagnostic assays, as marker vaccines, such as chimeric FMDV vaccines [47], the partial VP1 G-H loop vaccine [48], FMD-negative marker vaccines [49], a vaccine with an exogenous FLAG epitope in RGD-4 [136], the Cav-P1/3C R° FMDV vaccine [36], the 3AB-truncated virus and its…”
Section: Marker Vaccine Development and Diva Assaysmentioning
confidence: 99%