Insertion properties of cholesterylcyclodextrins in phospholipid membranes: a molecular study

Bauer, Martin; Charitat, Thierry; Fajolles, Christophe; Fragneto, Giovanna; Daillant, Jean

doi:10.1039/c1sm06346d

Cited by 13 publications

(25 citation statements)

References 36 publications

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“…Sliding Tethered Ligands (STLs) with a polyethylene glycol tether (PEG, <N> = 222) threaded through the cavity of a cholesteryl α‐cyclodextrin (cholesteryl α‐CD) and end‐capped with adamantane at both chain ends, were synthesized by LIONS laboratory (Saclay, France) within the framework of a common research program funded by the ANR (Agence Nationale pour la Recherche, France). All details on the synthesis and on the characterization of the materials (by Infra Red Absorption Reflection Spectroscopy, Brewster Angle Microscopy, Atomic Force Microscopy, Neutron scattering techniques) were reported previously or will appear shortly in forthcoming articles. Since adamantane forms a host‐guest complex with β‐CD, was also synthesized a cholesteryl β‐cylodextrin (cholesteryl β‐CD), as the receptor.…”

Section: Experimental Partmentioning

confidence: 99%

From Heterocoagulation to Biorecognition: Preparation of Surfaces for Direct Measurement of Their Interactions in a Surface Force Apparatus

Kékicheff

2014

Macromolecular Symposia

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Summary Due to the atomic resolution in surface separation accessible the Surface Force Apparatus technique provides an avenue for investigating the interactions in real systems, provided the model surfaces chosen for study have both equivalent intricate surface chemistry and structural properties. To overcome the difficulty of surface‐altering treatments when preparing suitable surfaces for the SFA and to realize interfaces fully representative of real systems immersed in solvents we have developed different experimental procedures. In particular, adsorption of nanoparticles from bulk colloidal dispersions, controlled solvent flow for coating substrates with polyelectrolytes multilayers, Langmuir Blodgett deposition of phospholipids membranes inserting ligands/receptors, all illustrate how one can get insights into subtle phenomena revealed by the force‐distance profiles when the true colloidal state is maintained, biomaterials are built and molecular recognition is involved.

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Section: Experimental Partmentioning

confidence: 99%

From Heterocoagulation to Biorecognition: Preparation of Surfaces for Direct Measurement of Their Interactions in a Surface Force Apparatus

Kékicheff

2014

Macromolecular Symposia

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“…31 However, it is unclear if this effect needs to be incorporated in models or if the technique, with its limited accessible Qz-range, 32 is insensitive to the effect. In one recent study the structure of a phospholipid monolayer was discussed with respect to changing surface pressure over the range 20-50 mN m -1 , 20 and in another an increase in density of the acyl chains layer with increasing surface pressure was discussed in the context of interactions with other species, 33 yet in both cases chain compaction with changing surface pressure was not considered explicitly. Other studies have also not taken into account this effect, 25,26 while in one study partial compaction of the acyl chains was implied by the parameters used although the effect was not discussed, 34 and in another it was discussed that a better fit to X-ray reflectivity data resulted using a higher density for the acyl chains although the reason was not resolved.…”

Section: Introductionmentioning

confidence: 99%

Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

Campbell

Saaka

Shao

et al. 2018

Journal of Colloid and Interface Science

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Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfactant and phospholipid monolayers at the air/water interface has not yet been established. To address this shortcoming, first a systematic evaluation of the suitability of different models is presented. The result is a comprehensive validation of an optimum model, which is evidently much needed in the field, and which we recommend as a starting point for future data treatment. While its limitations are openly discussed, consequences of failing to take into account various key aspects are critically examined and the systematic errors quantified. On the basis of this physical framework, we go on to show for the first time that neutron reflectometry can be used to quantify directly in situ at the air/water interface the extent of acyl chain compaction of phospholipid monolayers with respect to their phase. The achieved precision of this novel quantification is ∼10%. These advances together enhance significantly the potential for exploitation in future studies data from a broad range of systems including those involving synthetic polymers, proteins, DNA, nanoparticles and drugs.

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“…15 Due to the distinct physical and chemical properties of CDs, they are used in many fields, such as pharmaceuticals, 16 electroanalysis, 17 biotechnology, 18 environmental protection, 19 etc. Their special molecular structure -hydrophobic internal cavity and hydrophilic external surface -can form supramolecular host-guest complexes with a variety of hydrophobic molecules.…”

Section: Introductionmentioning

confidence: 99%

Correlation of polymer-like solution behaviors with electrospun fiber formation of hydroxypropyl-β-cyclodextrin and the adsorption study on the fiber

Zhang

Chen

Zha

et al. 2012

Phys. Chem. Chem. Phys.

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In this paper, the formation of hydroxypropyl-β-cyclodextrin (HPCD) nanofibers in electrospinning and the adsorption of organic molecules on the HPCD nanofiber were studied. The properties of a polymer-like solution from the highly concentrated HPCD/N,N-dimethylformamide (DMF) solution revealed HPCD supramolecular aggregates formation. The entanglements of HPCD self-organized aggregates were one of the most important factors that significantly influenced fiber formation during cyclodextrin electrospinning. The HPCD self-organized aggregates entanglement concentration (C(e)) was investigated. Analyzing the dependence of specific viscosity (η(sp)) on concentration enabled the determination of the aggregates unentangled and entangled regimes for HPCD polymer-like solutions. The dynamic light scattering (DLS) measurements and the (1)H NMR spectra of the HPCD solutions confirmed the presence of considerable HPCD self-organized aggregates in high concentrated HPCD/DMF solutions due to the intermolecular hydrogen bonding. The scanning electron microscopy (SEM) showed the electrospinning morphology transitioned from regular beads to uniform fibers with increasing the HPCD concentration. The dependence of the fiber diameter on the zero shear rate viscosity (η(0)) was determined. The static adsorption behavior of the HPCD fibers was studied. Neutral red (NR) was used as a model organic molecule. The adsorption of NR onto HPCD fibers fitted the pseudo-second-order kinetic model. The equilibrium adsorption amount of NR was 18.41 mg g(-1), and the apparent adsorption rate constant was 9.83 × 10(-4) g mg(-1) min(-1) at 25 °C.

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Insertion properties of cholesterylcyclodextrins in phospholipid membranes: a molecular study

Cited by 13 publications

References 36 publications

From Heterocoagulation to Biorecognition: Preparation of Surfaces for Direct Measurement of Their Interactions in a Surface Force Apparatus

From Heterocoagulation to Biorecognition: Preparation of Surfaces for Direct Measurement of Their Interactions in a Surface Force Apparatus

Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

Correlation of polymer-like solution behaviors with electrospun fiber formation of hydroxypropyl-β-cyclodextrin and the adsorption study on the fiber

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